Evidence map›Paper›PMID 37452887›Full record

SynthesisPsychopharmacology2023

Are medication effects on subjective response to alcohol and cue-induced craving associated? A meta regression study.

Lara A Ray, Steven J Nieto, Lindsay R Meredith, Elizabeth Burnette, Suzanna Donato, Molly Magill, Han Du

Open access · hybridAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Psychopharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 2 pooled it
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 syntheses or guidelines pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Lara A RayDepartment of Psychology, University of California at Los Angeles, 1285 Franz Hall, Box 951563, Los Angeles, CA, 90095-1563, USA. lararay@psych.ucla.edu.ORCID http://orcid.org/0000-0002-5734-9444
Steven J NietoDepartment of Psychology, University of California at Los Angeles, 1285 Franz Hall, Box 951563, Los Angeles, CA, 90095-1563, USA.
Lindsay R MeredithDepartment of Psychology, University of California at Los Angeles, 1285 Franz Hall, Box 951563, Los Angeles, CA, 90095-1563, USA.
Elizabeth BurnetteBrain Research Institute, University of California at Los Angeles, Los Angeles, CA, USA.
Suzanna DonatoDepartment of Psychology, University of California at Los Angeles, 1285 Franz Hall, Box 951563, Los Angeles, CA, 90095-1563, USA.
Molly MagillCenter for Alcohol and Addiction Studies, Brown University School of Public Health, Providence, RI, USA.
Han DuDepartment of Psychology, University of California at Los Angeles, 1285 Franz Hall, Box 951563, Los Angeles, CA, 90095-1563, USA.
University of California, Los Angeles · USBrown University · US

Funding

Clinical Neuroscience of Alcoholism: Integrating Neuroscience and Clinical TrialsK24AA025704 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LARA A. RAY · 2018 to 2026
$1.3M
Integrating findings across stages of medication development for AUDR21AA029771 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RAY, LARA A. · 2021 to 2022
$438k
Applying behavioral economics to screen medications for alcohol use disorderF32AA029288 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NIETO, STEVEN J · 2021 to 2022
$115k
Neuroimmune Treatment for AUD: Testing Moderators of Clinical Response and Mechanisms of ActionF31AA029295 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MEREDITH BROUSSARD, LINDSAY · 2022 to 2023
$59k
NIAAA NIH HHS F31 AA029295NIAAA NIH HHS F31AA029295NIAAA NIH HHS F32AA029288NIAAA NIH HHS K24AA025704NIAAA NIH HHS R21AA029771
6 · The paper itself

Abstract

rationaleAlcohol administration and cue-reactivity paradigms are frequently used to screen for the initial efficacy of medications for alcohol use disorder (AUD). While medication effects on the primary outcomes for these paradigms are assumed to be qualitatively related, there is a critical lack of quantitative evidence to support this hypothesis.

objectivesThe study aims to test the relationship between medication effect sizes on subjective response to alcohol administration and medication effect sizes for cue-induced craving to cue exposure, using meta-analysis.

methodsSystematic literature searches were conducted to identify randomized trials, wherein AUD medications were tested using the alcohol administration and/or cue-reactivity paradigms. From these studies, descriptive statistics were collected to compute medication effect sizes on the primary outcomes for each respective paradigm. With medication as the unit of analysis, medication effect sizes in alcohol administration studies were compared with medication effect sizes in cue-reactivity studies using the Williamson-York regression which allows for meta-regression across independent samples.

resultsMedication effect sizes on alcohol-induced stimulation and alcohol-induced craving were not significantly associated with medication effect sizes on cue-induced alcohol craving (k stimulation = 10 medications, [Formula: see text] and k craving = 11 medications, [Formula: see text] (SE = 0.237), [Formula: see text]), respectively. Medication effect sizes on alcohol-induced sedation were significantly associated with medication effects on cue-induced craving (k = 10 medications, [Formula: see text] (SE = 0.258), [Formula: see text]), such that medications that increased alcohol-induced sedation were more likely to reduce cue-induced alcohol craving.

conclusionsWith the exception of alcohol-induced sedation, there is little quantitative evidence of medication effects on subjective response domains measured during alcohol administration parallel medication effects on cue-induced alcohol craving. To provide additional context to the current study, future work should examine whether cue-reactivity findings predict clinical trial outcomes.

Indexed as

AlcoholismCravingAlcohol DrinkingCuesEthanolHumansEthanolAlcohol administrationAlcohol cravingAlcohol use disorderCue-reactivityPharmacotherapySedation

Identifiers

PMID37452887
PMCPMC10471658
OpenAlexW4384407963

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.