ArticleThe Journal of cell biology1986
The lateral diffusion of lipid probes in the surface membrane of Schistosoma mansoni.
Article in The Journal of cell biology, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Evaluation and experimental monitoring of calcium in plasma membrane inner nanoscale cytoplasm regions.Communications biology · 2025Article
- Chilling tolerance in Arabidopsis involves ALA1, a member of a new family of putative aminophospholipid translocases.The Plant cell · 2000Article
- Beta-very low density lipoprotein is sequestered in surface-connected tubules in mouse peritoneal macrophages.The Journal of cell biology · 1993Article
- Phospholipid transmembrane domains and lateral diffusion in fibroblasts.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- Anomalously slow mobility of fluorescent lipid probes in the plasma membrane of the yeast Saccharomyces cerevisiae.The Journal of membrane biology · 1993Article
- Distribution of a fluorescent ivermectin probe, bodipy ivermectin, in tissues of the nematode parasite Ascaris suum.Parasitology research · 1992Article
- A double surface membrane in plerocercoids of Ligula intestinalis (Cestoda: Pseudophyllidea).Parasitology research · 1992Article
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Authors and funding
6 authors.
Funding
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Abstract
The technique of fluorescence recovery after photobleaching was used to measure the lateral diffusion of fluorescent lipid analogues in the surface membrane of Schistosoma mansoni. Our data reveal that although some lipids could diffuse freely others exhibited restricted lateral diffusion. Quenching of lipid fluorescence by a non-permeant quencher, trypan blue, showed that there was an asymmetric distribution of lipids across the double bilayer of mature parasites. Those lipids that diffused freely were found to reside mainly in the external monolayer of the outer membrane whereas lipids with restricted lateral diffusion were located mainly in one or more of the monolayers beneath the external monolayer. Formation of surface membrane blebs allowed us to measure the lateral diffusion of lipids in the membrane without the influence of underlying cytoskeletal structures. The restricted diffusion found on the normal surface membrane of mature parasites was found to be released in membrane blebs. Quenching of fluorescent lipids on blebs indicated that all probes were present almost entirely in the external monolayer. Juvenile worms exhibited lower lateral diffusion coefficients than mature parasites: in addition, the lipids partitioned into the external monolayer. The results are discussed in terms of membrane organization, cytoskeletal contacts, and biological significance.
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