ArticleESC heart failure2023
Causality between heart failure and epigenetic age: a bidirectional Mendelian randomization study.
Article in ESC heart failure, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Spleen volume in relation to ulcerative colitis and Crohn's disease: a Mendelian randomization study.Scientific reports · 2025Pooled it
- Biological age acceleration predicts mortality and heart failure after acute myocardial infarction in older adults.Journal of geriatric cardiology : JGC · 2026Article
- Epigenetic age acceleration in young adults with congenital heart disease.Clinical epigenetics · 2026Article
- Global burden of heart failure due to cardiovascular diseases, 1990-2021 and predictions to 2035 based on GBD 2021.ESC heart failure · 2026Article
- Effect of unaccompanied care model in postoperative care for elderly patients with lower limb fractures: factors influencing postoperative heart failure.American journal of translational research · 2026Article
- A pilot study on DNA methylation changes for non-invasive molecular diagnostics in heart failure.ESC heart failure · 2025Observational
- Genetic evidence for causal effects of inflammatory protein factors on breast cancer.Discover oncology · 2025Article
- Genetic evidence for causal relationships between vegetarian biomarkers and esophageal cancer risk.Discover oncology · 2025Article
- Epigenetic age acceleration and allergic diseases: a bidirectional two-sample Mendelian randomization study.Clinical epigenetics · 2025Article
- Causal analysis of 731 immunophenotypes and heart failure: A bidirectional Mendelian randomization study.Medicine · 2025Article
- Causal Associations of Epigenetic Age Acceleration With Stroke and Its Functional Outcome: A Two-Sample, Two-Step Mendelian Randomization Study.Brain and behavior · 2025Article
- Assessing inflammatory protein factors in inflammatory bowel Disease using multivariable mendelian randomization.Scientific reports · 2025Article
- Genetic Evidence for Causal Effects of Immune Cell Subtypes on Postherpetic Neuralgia.Journal of pain research · 2025Article
- Elucidating the Causal Impact of Dietary Factors on Rheumatoid Arthritis: Insights From Multivariable Mendelian Randomization Analysis.Food science & nutrition · 2024Article
- Causal association between epigenetic age acceleration and two pulmonary vascular diseases: pulmonary arterial hypertension and pulmonary embolism-a bidirectional Mendelian study.Clinical epigenetics · 2024Article
- Causal association of epigenetic age acceleration and risk of subacute thyroiditis: a bidirectional Mendelian randomization study.Clinical epigenetics · 2024Article
- Causal association of obesity with epigenetic aging and telomere length: a bidirectional mendelian randomization study.Lipids in health and disease · 2024Article
- Epigenetic age acceleration and risk of aortic valve stenosis: a bidirectional Mendelian randomization study.Clinical epigenetics · 2024Article
- DNA Methylation and Telomeres-Their Impact on the Occurrence of Atrial Fibrillation during Cardiac Aging.International journal of molecular sciences · 2023Review
- Causality between heart failure and epigenetic age: a bidirectional Mendelian randomization study.ESC heart failure · 2023Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
aimsHeart failure (HF) is a prevalent age-related cardiovascular disease with poor prognosis in the elderly population. This study aimed to establish the causal relationship between ageing and HF by conducting a bidirectional Mendelian randomization (MR) analysis on epigenetic age (a marker of ageing) and HF. METHODS AND
resultsGenome-wide association study data for epigenetic age (GrimAge, HorvathAge, HannumAge, and PhenoAge) and HF were collected and assessed for significant genetic variables. A bidirectional MR analysis was carried out using the random-effects inverse-variance weighted (IVW) method as the primary approach, while other methods (MR-Egger, weighted median, simple mode, and weighted mode) and multiple sensitivity analyses (heterogeneity analysis, leave-one-out sensitivity analysis, and horizontal pleiotropy analysis) were employed to evaluate the impact of epigenetic age on HF and vice versa. Bidirectional MR analysis of two samples revealed that the epigenetic PhenoAge clock increased the risk of HF [IVW odds ratio (OR) 1.015, 95% confidence interval (CI) 1.002-1.028, P = 0.028 and weighted median OR 1.020, 95% CI 1.001-1.038, P = 0.039]. Other results were not statistically significant.
conclusionsThe bidirectional MR analysis demonstrated a causal link between genetically predicted epigenetic age and HF in individuals of European descent. Further research into epigenetic age in other populations and additional genetic information related to HF is warranted.
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