ArticleBMC psychology2023
Impact of depression on the perception of fatigue and information processing speed in a cohort of multiple sclerosis patients.
Article in BMC psychology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 8 citations in OpenAlex.
- Dissociating Fatigue and Fatigability in Multiple Sclerosis: The Role of Cognitive Processing Speed.European journal of neurology · 2026Article
- The Relationship Between Subjective and Objective Fatigue Assessment Approaches in Multiple Sclerosis: A Meta-Analysis.Neuropsychology review · 2026Review
- Subjective mental fatigue mediates the relationship between information processing speed and verbal memory deficits in multiple sclerosis.Scientific reports · 2026Article
- Cognitive Functioning in Toxic Oil Syndrome Survivors: A Case-Control Study Four Decades After the Epidemic.Journal of clinical medicine · 2025Article
- Biomarkers of Progression Independent of Relapse Activity-Can We Actually Measure It Yet?International journal of molecular sciences · 2025Review
- Factors influencing fatigue among patients undergoing hemodialysis: a multi-center cross-sectional study.The Libyan journal of medicine · 2024Article
- Cognitive Impairment, Associated Clinical Factors, and MR Volumetric Measures in Myelin Oligodendrocyte Glycoprotein-IgG-Associated Disease.Neurology(R) neuroimmunology & neuroinflammation · 2024Article
- Review
- Brain microstructure is linked to cognitive fatigue in early multiple sclerosis.Journal of neurology · 2024Article
- Article
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInformation processing speed is commonly impaired in people with multiple sclerosis (PwMS). However, depression and fatigue can affect the cognitive profile of patients: fatigue has a negative impact from the disease's earliest stage and a reduced information processing speed is often associated with higher levels of depression. Therefore, the aim of this study was to investigate the correlations between information processing speed and physical fatigue in a cohort of Italian PwMS from a single center, considering the effect of depression.
methodsTwo hundred (W = 128; mean age = 39.83 years; SD = 11.86) PwMS, from the Bari University Hospital, underwent testing for processing speed (Symbol Digit Modalities Test [SDMT]), fatigue level (Fatigue Severity Scale [FSS]), and depression (Beck's Depression Inventory [BDI]).
resultsStatistically significant correlations emerged between SDMT and FSS, SDMT and BDI, FSS and BDI. Mediation analyses revealed that while physical fatigue had no significant direct negative effect on information processing speed (z=-0.891; p > 0.05), depression predicted the relationship between fatigue and information processing speed (z=-2.181; p < 0.05).
conclusionOur findings showed that cognitive performance at SDMT was not affected by patients' perceived level of physical fatigue, but by depression. The presence of a high BDI score mediates the physical fatigue on cognitive performance impact.
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