ArticleBMC oral health2023
The efficacy of concentrated growth factor and platelet-rich fibrin as scaffolds in regenerative endodontic treatment applied to immature permanent teeth: a retrospective study.
Article in BMC oral health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy of concentrated growth factor compared with other types of regenerative endodontic procedures: a systematic review.BMC oral health · 2025Pooled it
- Article
- Effect of Autologous Bioactive Concentrated Growth Factor and Residual Dental Pulp on Dentin-Pulp Complex Regeneration.Biomedicines · 2026Article
- Assessment of regenerative endodontic procedures using platelet-rich fibrin in immature necrotic teeth.Bioinformation · 2026Article
- Does platelet-rich fibrin improve the clinical outcomes of intentional replantation in the treatment of periodontally hopeless teeth?European oral research · 2026Article
- Platelet-Rich Plasma and Platelet-Rich Fibrin in Endodontics: A Scoping Review.International journal of molecular sciences · 2025Article
- Article
- The effect of citric acid on mineralisation and vascular endothelial growth factor secretion from apical papilla stem cells.Acta odontologica Scandinavica · 2024Article
- Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this retrospective study was to compare the efficacy of concentrated growth factor (CGF) and platelet-rich fibrin (PRF) as scaffolds in regenerative endodontic therapy (RET).
methodsNecrotic immature permanent teeth treated with regenerative endodontic therapy during January 2018 to August 2022 were divided into the CGF and PRF groups according to the scaffold. The CGF and PRF groups included 7 and 6 teeth, respectively. The efficacy of regenerative endodontic therapy was analyzed based on the clinical and radiological outcomes at three different follow up periods: T1 (3-6 months), T2 (6-12 months) and T3 (12-24 months). Statistical analysis was performed using the independent T test, Mann-Whitney test and Fisher's exact test at a significance level of 0.05.
resultsThe success rate of each stage in both groups was 100%. Through quantitative comparison of radiographic outcomes, there was no statistically significant difference between the two groups in terms of root development and periapical lesion healing at each stage, except that the increase rate of radiographic root area in PRF group in the T3 stage was above one in CGF group with statistically significance.
conclusionsBoth CGF and PRF had a similar clinical performance regarding resolution of clinical signs and symptoms, periapical lesion healing, and continued root development as scaffolds in RET. Further prospective studies with large samples for longer follow-up periods are needed.
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