ArticleScientific reports2023
Evaluating the global, regional, and national impact of syphilis: results from the global burden of disease study 2019.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Initial physical health assessment for psychosis in Australia and New Zealand: 2026 recommendations.The Australian and New Zealand journal of psychiatry · 2026Guideline
- Looking Down the Road: Development of a Future Syphilis Vaccine.Sexually transmitted diseases · 2026Article
- Comparable treatment response rates with benzathine penicillin and doxycycline in early syphilis: evidence from a large German cohort.Infection · 2026Article
- Predicting the incidence of syphilis in China using Baidu search index and an ARIMAX model.BMC infectious diseases · 2026Article
- The mediating role of coping strategies in the relationship between stigma and quality of life among syphilis patients.Scientific reports · 2026Article
- Participatory development of strategies to combat congenital syphilis: action research.Revista latino-americana de enfermagem · 2026Article
- Clinical characteristics and cause analysis of false-positive results in treponemal testing among patients.Annals of medicine · 2025Article
- The Great Imitator: A Case of Secondary Neurosyphilis With Unusual Neurological Manifestations.Cureus · 2025Article
- Epidemiological analysis of syphilis trends, disparities, and public health implications in the United States, 2018-2022.BMC infectious diseases · 2025Article
- Article
- Coinfection of syphilis and HIV: epidemiological evaluation at the Dermatology Department in Lodz, Poland.Postepy dermatologii i alergologii · 2025Article
- Demographic inaccuracies and biases in the depiction of patients by artificial intelligence text-to-image generators.NPJ digital medicine · 2025Article
- Clinical features in four patients with syphilitic outer retinopathy.Japanese journal of ophthalmology · 2025Article
- Alternative treponemal serology assays for diagnosis and confirmation of syphilis in a diagnostic laboratory: a retrospective evaluation of four agglutination assays and one ELISA.Journal of clinical microbiology · 2025Article
- B-Cell Epitope Mapping of theDiagnostics (Basel, Switzerland) · 2025Article
- The global burden of osteoarthritis knee: a secondary data analysis of a population-based study.Clinical rheumatology · 2025Article
- Global burden of HIV, syphilis, and HBV infection among women of childbearing age and children under five: based on the Global Burden of Diseases Study 2021.Frontiers in public health · 2025Article
- Time-course transcriptomics reveals the impact ofFrontiers in microbiology · 2025Article
- Age-period-cohort analysis of syphilis epidemics in Eastern China, China, 2005-2024.Frontiers in public health · 2025Article
- Global, regional, and national burden and trends of syphilis among women of childbearing age from 1990 to 2021.Frontiers in public health · 2025Article
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Syphilis is a global public health concern. This study aimed to assess the global and regional burden of syphilis from 1990 to 2019. Disease burden was evaluated using disability-adjusted life-years (DALYs) and prevalence. Data were extracted from the 2019 global burden of disease Study, an open database available for download. Age-standardized rates (ASR) and estimated annual percentage changes (EAPC) were calculated to evaluate the syphilis burden over time. In 2019, the total number of prevalent cases of syphilis was 49.71 million worldwide. The ASR of prevalence was stable from 1990 to 2019 with an EAPC of 0.00 (95% CI - 0.10-0.11). The number of DALYs caused by syphilis was 7.36 million in 2019, reflecting a reduction of 16.38% compared with that in 1990 (8.80 million). The ASR of DALYs exhibited a decreasing trend from 1990 to 2019 (EAPC = - 1.01; 95% CI - 1.19 to - 0.84), with the highest rates observed in the younger age group (< 14 years old). In 2019, the highest ASR of DALYs was found in low sociodemographic index (SDI) regions (239.21/100,000), and the lowest in high SDI regions (3.14/100,000). Generally, the ASR of DALYs decreased as the SDI increased. The top three countries with the highest ASR of DALYs for syphilis were the Solomon Islands, Equatorial Guinea, and Liberia. While the global prevalence of syphilis remained persistently high from 1990 to 2019, there has been a recent decrease in the ASR of DALYs. Increased attention should be dedicated to younger populations and regions characterized by low SDIs.
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