Evidence map›Paper›PMID 37451841›Full record

ArticleJournal of clinical pathology2024

NTRK gene alterations were enriched in hepatoid or enteroblastic differentiation type of gastric cancer.

Xiaohong Pu, Yao Fu, Qi Sun, Lin Li, Attigah Kwasi, Ziyan Ma, Xiangshan Fan, Beicheng Sun

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical pathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Gastric Adenocarcinoma with Enteroblastic Differentiation.Pathobiology : journal of immunopathology, molecular and cellular biology · 2025
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Xiaohong Pu *Department of Pathology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.ORCID http://orcid.org/0000-0002-8870-148X
Yao Fu *Department of Pathology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Qi Sun *Department of Pathology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Lin LiDepartment of Pathology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Attigah KwasiNanjing Medical University, Nanjing, China.
Ziyan MaNew York University, New York City, New York, USA.
Xiangshan FanDepartment of Pathology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China sunbc@nju.edu.cn fanxiangshan@nju.edu.cn.
Beicheng SunMedical School, Nanjing University, Nanjing, China sunbc@nju.edu.cn fanxiangshan@nju.edu.cn.
Nanjing Drum Tower Hospital · CNNanjing Medical University · CNNew York University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

methodsOur study comprised 51 cases of EBV(Epstein-barr virus)-associated gastric carcinomas, 94 cases of dMMR GC, 90 cases of gastric adenocarcinoma with hepatoid or enteroblastic differentiation (GAHED) and 256 cases of conventional GC. Furthermore, to investigate the connection between NTRK fusion and dMMR proteins, we collected dMMR tumours of various types, including 21 cases of duodenal adenocarcinomas, 46 endometrioid carcinomas and 82 CRCs. NTRK fusion and amplification were screened in GC and various types of dMMR tumours using fluorescence in situ hybridisation (FISH), while cases positive for FISH translocation underwent next-generation sequencing testing.

resultsOur findings revealed the existence of two cases each of NTRK fusions and NTRK amplifications, which were all enriched in case of GAHED. Additionally, following an analysis of several types of cancers, we discovered that NTRK gene alterations were only present in dMMR CRC.

conclusionsOur results indicate that NTRK gene alterations are not enriched in GC with dMMR but are specifically enriched in cases of GAHED.

Indexed as

Stomach NeoplasmsAdenocarcinomaAdultAgedAged, 80 and overBiomarkers, TumorCell DifferentiationDNA Mismatch RepairFemaleGene AmplificationHumansIn Situ Hybridization, FluorescenceMaleMiddle AgedOncogene Proteins, FusionReceptor, trkABiomarkers, TumorNTRK1 protein, humanOncogene Proteins, FusionReceptor, trkAgastric cancergastroenterologygastrointestinal diseasesgastrointestinal neoplasmsgene amplification

Identifiers

PMID37451841
PMCPMC11474252
OpenAlexW4384297648

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.