Evidence map›Paper›PMID 37451823›Full record

ArticleGenome research2023

Ultra-long-range interactions between active regulatory elements.

Elias T Friman, Ilya M Flyamer, Davide Marenduzzo, Shelagh Boyle, Wendy A Bickmore

Open access · bronzeAbstract read
In one paragraph

Article in Genome research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 50 citations in OpenAlex.

  1. Transcription and Three-Dimensional Genome Organization: Cause, Consequence, or Coordination?BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
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  14. Transcriptional condensates encode a "golden mean" to optimize enhancer-promoter communication across genomic distances.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  15. Article
  16. Article
  17. The Biological Function of Genome Organization.International journal of molecular sciences · 2025
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Elias T FrimanMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh EH4 2XU, United Kingdom; Elias.Friman@ed.ac.uk Wendy.Bickmore@ed.ac.uk.ORCID 0000-0001-9944-6560
Ilya M FlyamerMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh EH4 2XU, United Kingdom.ORCID 0000-0002-4892-4208
Davide MarenduzzoSchool of Physics and Astronomy, University of Edinburgh, Edinburgh EH9 3FD, United Kingdom.
Shelagh BoyleMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh EH4 2XU, United Kingdom.
Wendy A BickmoreMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh EH4 2XU, United Kingdom; Elias.Friman@ed.ac.uk Wendy.Bickmore@ed.ac.uk.ORCID 0000-0001-6660-7735
Institute of Genetics and Cancer · GBUniversity of Edinburgh · GB

Funding

Medical Research Council MC_UU_00007/2Medical Research Council MC_UU_00035/7
6 · The paper itself

Abstract

Contacts between enhancers and promoters are thought to relate to their ability to activate transcription. Investigating factors that contribute to such chromatin interactions is therefore important for understanding gene regulation. Here, we have determined contact frequencies between millions of pairs of

Indexed as

ChromatinRegulatory Sequences, Nucleic AcidCCCTC-Binding FactorCell Cycle ProteinsEnhancer Elements, GeneticGene Expression RegulationPolycomb-Group ProteinsPromoter Regions, GeneticCCCTC-Binding FactorCell Cycle ProteinsChromatinPolycomb-Group Proteins

Identifiers

PMID37451823
PMCPMC10547262
OpenAlexW4384338924

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.