Evidence map›Paper›PMID 37451558›Full record

ArticleThe Journal of nutrition2023

Growth in Infancy and Childhood and Age at Menarche in Five Low- or Middle-Income Countries: Consortium of Health Orientated Research in Transitional Societies (COHORTS).

Lukhanyo H Nyati, Shane A Norris, Lisa K Micklesfield, Linda S Adair, Caroline Fall, Nanette R Lee, Reynaldo Martorell, Clive Osmond, Linda M Richter, Harshpal S Sachdev and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 6 countries.

Lukhanyo H NyatiSAMRC Developmental Pathways for Health Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Interprofessional Education Unit, Faculty of Community and Health Sciences, University of Western Cape, Cape Town, South Africa.
Shane A NorrisSAMRC Developmental Pathways for Health Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; School of Human Development and Health and NIHR Southampton Biomedical Research Centre, University of Southampton, Southampton, United Kingdom. Electronic address: Shane.Norris@wits.ac.za.
Lisa K MicklesfieldSAMRC Developmental Pathways for Health Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Linda S AdairDepartment of Nutrition, University of North Carolina, Chapel Hill, NC, United States.
Caroline FallMRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, United Kingdom.
Nanette R LeeUSC-Office of Population Studies Foundation, Inc., and Department of Anthropology, Sociology, and History, University of San Carlos, Cebu City, Philippines.
Reynaldo MartorellHubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, United States.
Clive OsmondMRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, United Kingdom.
Linda M RichterDSI-NRF Centre of Excellence in Human Development, University of the Witwatersrand, Johannesburg, South Africa.
Harshpal S SachdevSitaram Bhartia Institute of Science and Research, New Delhi, India.
Bernardo HortaPost-Graduate Program in Health and Behaviour, Universidade Católica de Pelotas, Pelotas, Brazil.
Aryeh D SteinSAMRC Developmental Pathways for Health Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, United States.
COHORTS Group
South African Medical Research Council · ZAMRC Lifecourse Epidemiology Unit · GBEmory University · USSitaram Bhartia Institute of Science and Research · INUniversidade Católica de Pelotas · BRUniversity of North Carolina at Chapel Hill · USUniversity of San Carlos · PHUniversity of the Witwatersrand · ZA

Funding

British Heart FoundationMedical Research Council MC_PC_MR/R018545/1Medical Research Council MC_UP_A620_1016Medical Research Council MC_UU_12011/3Wellcome Trust 089257/Z/09/Z
6 · The paper itself

Abstract

backgroundEarlier age at menarche is associated with behavioral and noncommunicable disease risks. The influence of birth weight (BW) (intrauterine) and postnatal growth on age at menarche is not well studied in low- and middle-income countries (LMICs).

objectiveTherefore, we investigated these associations in 5 LMIC birth cohorts.

methodsWe analyzed data from Brazil, Guatemala, India, the Philippines, and South Africa (n = 3983). We derived stunting (< -2 SD scores) at 24 mo using the WHO child growth standards. We generated interaction terms with categorized BW and conditional weight (lighter < 0 or heavier ≥ 0), and height (shorter < 0 or taller ≥ 0) z-scores. We categorized early-, modal-, and late-onset menarche and used multilevel ordinal regression. We used multilevel linear regression on continuous age at menarche.

resultsMean age at menarche was 12.8 y (95% CI: 12.7 12.9). BW was not associated with age at menarche. Conditional height at 24 mo and mid-childhood (OR: 1.35; 95% CI: 1.27, 1.44 and 1.32; 1.25, 1.41, respectively) and conditional weight at 24 mo and mid-childhood (OR: 1.15; 1.08, 1.22 and 1.18; 1.11, 1.25, respectively) were associated with increased likelihood of early-onset menarche. Being heavier at birth and taller at 24 mo was associated with a 4-mo (95% CI: 0.8, 7.6) earlier age at menarche than being lighter at birth and shorter at 24 mo. Being heavier at birth but lighter in mid-childhood was associated with a 3-mo (95% CI: 0.8, 4.8) later age at menarche than being lighter at birth and mid-childhood. Age at menarche was 7 mo later in stunted than nonstunted girls.

conclusionAge at menarche is inversely related to relative weight gain but also to rapid linear growth among those born shorter but remained stunted, and those born taller and grew excessively. These findings do not deter the global health goal to reduce growth faltering but emphasize the potential adverse effects of an obesogenic environment on adolescent development.

Indexed as

Developing CountriesMenarcheAdolescentBirth WeightBody HeightChildChild DevelopmentFemaleHumansInfantInfant, NewbornProspective Studiesage at menarchebirth cohortinfantlinear growthlow- and middle-income countriesobesityweight gain

Identifiers

PMID37451558
PMCPMC10517227
OpenAlexW4384008996

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.