Evidence map›Paper›PMID 37451262›Full record

ArticleMolecular cell2023

mRNA stability and m

Inga Loedige, Artem Baranovskii, Samantha Mendonsa, Sayaka Dantsuji, Niko Popitsch, Laura Breimann, Nadja Zerna, Vsevolod Cherepanov, Miha Milek, Stefan Ameres and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Molecular cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
12.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 83 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. mNature reviews. Neuroscience · 2026
    Review
  6. Review
  7. Article
  8. A neurocutaneous NaScience advances · 2026
    Article
  9. Article
  10. Article
  11. Methylation marks breast cancer metastasis: The roles of mThe Journal of biological chemistry · 2026
    Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Bioluminescent Probes for Multiplexed RNA Imaging.Journal of the American Chemical Society · 2026
    Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Inga LoedigeBerlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine, Berlin 10115, Germany.
Artem BaranovskiiBerlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine, Berlin 10115, Germany.
Samantha MendonsaBerlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine, Berlin 10115, Germany.
Sayaka DantsujiBerlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine, Berlin 10115, Germany.
Niko PopitschMax Perutz Labs, University of Vienna, Vienna BioCenter, 1030 Vienna, Austria.
Laura BreimannBerlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine, Berlin 10115, Germany; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Nadja ZernaBerlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine, Berlin 10115, Germany.
Vsevolod CherepanovBerlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine, Berlin 10115, Germany.
Miha MilekBerlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine, Berlin 10115, Germany.
Stefan AmeresMax Perutz Labs, University of Vienna, Vienna BioCenter, 1030 Vienna, Austria.
Marina ChekulaevaBerlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine, Berlin 10115, Germany. Electronic address: marina.chekulaeva@mdc-berlin.de.
Max Delbrück Center · DEUniversity of Vienna · ATHarvard University · US

Funding

Center for Genome ImagingRM1HG011016 · NHGRI · HARVARD MEDICAL SCHOOL · PI WU, CHAO-TING · 2021 to 2025
$12.2M
NHGRI NIH HHS RM1 HG011016
6 · The paper itself

Abstract

For cells to perform their biological functions, they need to adopt specific shapes and form functionally distinct subcellular compartments. This is achieved in part via an asymmetric distribution of mRNAs within cells. Currently, the main model of mRNA localization involves specific sequences called "zipcodes" that direct mRNAs to their proper locations. However, while thousands of mRNAs localize within cells, only a few zipcodes have been identified, suggesting that additional mechanisms contribute to localization. Here, we assess the role of mRNA stability in localization by combining the isolation of the soma and neurites of mouse primary cortical and mESC-derived neurons, SLAM-seq, m

Indexed as

NeuritesNeuronsAnimalsCodonMiceRNA, MessengerRNA StabilityCodonRNA, Messenger5' terminal oligopyrimidine tracts5'TOPsAREsAU-rich elementscodon optimalitym(6)AmRNA localizationmRNA stabilityneuronRBPsRNA-binding proteinszipcodes

Identifiers

PMID37451262
PMCPMC10529935
OpenAlexW4384207566

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.