Evidence map›Paper›PMID 37451164›Full record

ReviewCurrent opinion in genetics & development2023

Recent advances in stem cell-based blastocyst models.

Seiya Oura, James N Hamilton, Jun Wu

Abstract readReview
In one paragraph

Review in Current opinion in genetics & development, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Current strategies using 3D organoids to establishJournal of veterinary science · 2024
    Review
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Seiya OuraDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
James N HamiltonDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Jun WuDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA; Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA; Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: jun2.wu@utsouthwestern.edu.

Funding

Dissect the mechanisms underlying interspecies pluripotent stem cell competitionR01HD103627 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI Michael Buszczak, Ondine B Cleaver · 2022 to 2026
$1.8M
Dissect formative pluripotency using cultured pluripotent stem cellsR01GM138565 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI WU, JUN · 2021 to 2025
$1.7M
Derivation of chimera competent pig embryonic stem cells under a novel conditionR21OD028763 · OD · UT SOUTHWESTERN MEDICAL CENTER · PI WU, JUN · 2020 to 2021
$452k
NICHD NIH HHS R01 HD103627NIGMS NIH HHS R01 GM138565NIH HHS R21 OD028763
6 · The paper itself

Abstract

Early embryo development is a highly dynamic process that plays a crucial role in determining the health and characteristics of an organism. For many years, embryonic and extraembryonic stem cell lines representing various developmental stages have served as valuable models for studying early embryogenesis. As our understanding of stem cell culture and embryo development has advanced, researchers have been able to create more sophisticated 3D structures mimicking early embryos, such as blastocyst-like structures (blastoids). These innovative models represent a significant leap forward in the field. In this mini-review, we will discuss the latest progress in stem cell-based embryo models, explore potential future directions, and examine how these models contribute to a deeper understanding of early mammalian development.

Indexed as

BlastocystStem CellsAnimalsCell DifferentiationCell LineEmbryo, MammalianEmbryonic DevelopmentMammals

Identifiers

PMID37451164
PMCPMC12077647

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.