Evidence map›Paper›PMID 37450884›Full record

ArticleACS synthetic biology2023

Bioluminescent Genetically Encoded Glutamate Indicators for Molecular Imaging of Neuronal Activity.

Eric D Petersen, Alexandra P Lapan, E Alejandro Castellanos Franco, Adam J Fillion, Emmanuel L Crespo, Gerard G Lambert, Connor J Grady, Albertina T Zanca, Richard Orcutt, Ute Hochgeschwender and 2 more

Open access · greenAbstract read
In one paragraph

Article in ACS synthetic biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. CaBLAM! A high-contrast bioluminescent CabioRxiv : the preprint server for biology · 2025
    Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Engineering luminopsins with improved coupling efficiencies.bioRxiv : the preprint server for biology · 2023
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Eric D PetersenDepartment of Chemical Engineering and Materials Science, Michigan State University, East Lansing, Michigan 48824, United States.ORCID 0000-0002-3138-6431
Alexandra P LapanDepartment of Chemical Engineering and Materials Science, Michigan State University, East Lansing, Michigan 48824, United States.
E Alejandro Castellanos FrancoDepartment of Biomedical Engineering, Michigan State University, East Lansing, Michigan 48824, United States.
Adam J FillionDepartment of Chemical Engineering and Materials Science, Michigan State University, East Lansing, Michigan 48824, United States.
Emmanuel L CrespoCollege of Medicine, Central Michigan University, Mount Pleasant, Michigan 48859, United States.
Gerard G LambertDepartment of Neurosciences, University of California San Diego School of Medicine, La Jolla, California 92093, United States.
Connor J GradyDepartment of Biomedical Engineering, Michigan State University, East Lansing, Michigan 48824, United States.ORCID 0000-0003-3340-512X
Albertina T ZancaDepartment of Neurosciences, University of California San Diego School of Medicine, La Jolla, California 92093, United States.
Richard OrcuttDepartment of Neurosciences, University of California San Diego School of Medicine, La Jolla, California 92093, United States.
Ute HochgeschwenderCollege of Medicine, Central Michigan University, Mount Pleasant, Michigan 48859, United States.
Nathan C ShanerDepartment of Neurosciences, University of California San Diego School of Medicine, La Jolla, California 92093, United States.
Assaf A GiladDepartment of Chemical Engineering and Materials Science, Michigan State University, East Lansing, Michigan 48824, United States.ORCID 0000-0002-7272-7570
Michigan State University · USUniversity of California San Diego · USCentral Michigan University · US

Funding

Training/Dissemination-Resource for Molecular Imaging Agents in Precision MedicineP41EB024495 · NIBIB · UT SOUTHWESTERN MEDICAL CENTER · PI MARTIN G POMPER · 2017 to 2026
$11.8M
Clinically Translatable MRI Reporter Genes and Imaging Methods with Ultra-High Specificity and SensitivityR01EB031008 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI CHRISTIAN T FARRAR · 2021 to 2026
$4.0M
Bioengineering a novel electromagnetic perspective gene as a tool for wireless control of excitable cellsR01NS098231 · NINDS · MICHIGAN STATE UNIVERSITY · PI GILAD, ASSAF A, PELLED, GALIT · 2017 to 2021
$2.6M
Evolution and optimization of synthetic <READ/WRITE> function from and into cells using genetic programmingR01EB030565 · NIBIB · MICHIGAN STATE UNIVERSITY · PI BANZHAF, WOLFGANG, GILAD, ASSAF A · 2021 to 2024
$2.3M
Semi-synthetic, magneto-photonic circuit for non-invasive control of cellular functionR01EB031936 · NIBIB · CENTRAL MICHIGAN UNIVERSITY · PI GILAD, ASSAF A, HOCHGESCHWENDER, UTE H · 2021 to 2021
$2.0M
Molecular Imaging for Detection of Synthetic Biology Circuits, Oscillators and Toggle Switches in Regenerative MedicineR01NS104306 · NINDS · MICHIGAN STATE UNIVERSITY · PI GILAD, ASSAF A · 2018 to 2021
$1.3M
NIBIB NIH HHS P41 EB024495NIBIB NIH HHS R01 EB030565NIBIB NIH HHS R01 EB031008NIBIB NIH HHS R01 EB031936NINDS NIH HHS R01 NS098231NINDS NIH HHS R01 NS104306
6 · The paper itself

Abstract

Genetically encoded optical sensors and advancements in microscopy instrumentation and techniques have revolutionized the scientific toolbox available for probing complex biological processes such as release of specific neurotransmitters. Most genetically encoded optical sensors currently used are based on fluorescence and have been highly successful tools for single-cell imaging in superficial brain regions. However, there remains a need to develop new tools for reporting neuronal activity

Indexed as

Biosensing TechniquesGlutamic AcidBrainHumansMolecular ImagingNeurotransmitter AgentsGlutamic AcidNeurotransmitter Agentsbioluminescencebioluminescentneuroimagingneurotransmitteroptical sensorsoptogenetics

Identifiers

PMID37450884
PMCPMC10443529
OpenAlexW4384282203

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.