Evidence map›Paper›PMID 37450338›Full record

ArticleAIDS research and human retroviruses2023

Viral Persistence in the Gut-Associated Lymphoid Tissue and Barriers to HIV Cure.

Francesca Cossarini, Judith A Aberg, Benjamin K Chen, Saurabh Mehandru

Open access · greenAbstract read
In one paragraph

Article in AIDS research and human retroviruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Francesca CossariniDivision of Infectious Diseases, Department of Medicine, Icahn School at Mount Sinai, New York, New York, USA.ORCID 0000-0002-8793-5241
Judith A AbergDivision of Infectious Diseases, Department of Medicine, Icahn School at Mount Sinai, New York, New York, USA.
Benjamin K ChenDivision of Infectious Diseases, Department of Medicine, Icahn School at Mount Sinai, New York, New York, USA.
Saurabh MehandruPrecision Immunology Institute, Icahn School at Mount Sinai, New York, New York, USA.
Icahn School of Medicine at Mount Sinai · US

Funding

Conduits: Mount Sinai Health System Translational Science HubUL1TR004419 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2022 to 2026
$46.4M
Institutional Career Development CoreKL2TR004421 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Inga Peter · 2022 to 2026
$6.2M
Single cell transcriptomics of HIV persistence and latencyR01AI162223 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CHEN, BENJAMIN K · 2021 to 2025
$3.3M
HIV immune evasion and escape through T cell virological synapsesR37AI148064 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BENJAMIN K CHEN · 2022 to 2026
$3.1M
NCATS NIH HHS KL2 TR004421NCATS NIH HHS UL1 TR004419NIAID NIH HHS R01 AI162223NIAID NIH HHS R37 AI148064
6 · The paper itself

Abstract

More than 40 years after the first reported cases of what then became known as acquired immunodeficiency syndrome (AIDS), tremendous progress has been achieved in transforming the disease from almost universally fatal to a chronic manageable condition. Nonetheless, the efforts to find a preventative vaccine or a cure for the underlying infection with Human Immunodeficiency Virus (HIV) remain largely unsuccessful. Many challenges intrinsic to the virus characteristics and host response need to be overcome for either goal to be achieved. This article will review the obstacles to an effective HIV cure, specifically the steps involved in the generation of HIV latency, focusing on the role of the gut-associated lymphoid tissue, which has received less attention compared with the peripheral blood, despite being the largest repository of lymphoid tissue in the human body, and a large site for HIV persistence.

Indexed as

HIVmucosal immunologypersistence

Identifiers

PMID37450338
PMCPMC10790554
OpenAlexW4384339019

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.