Evidence map›Paper›PMID 37450258›Full record

ArticleIrish journal of medical science2024

Pilot study of the implementation of G8 screening tool, Cognitive screening assessment and Chemotherapy Toxicity assessment in older adults with cancer in a Tertiary University Hospital in Ireland.

Maha AlSendi, Calvin R Flynn, Muhammad R Khan, Paul Selvadurai, John Crown, Raymond S McDermott, Janice M Walshe, David W Fennelly, Emer O Hanrahan, Mark Doherty and 1 more

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Article in Irish journal of medical science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Maha AlSendiDepartment of Medical Oncology, St. Vincent's University Hospital, Elm Park, Dublin 4, Ireland. mahaalsindi@gmail.com.ORCID http://orcid.org/0000-0003-2806-7568
Calvin R FlynnDepartment of Medical Oncology, St. Vincent's University Hospital, Elm Park, Dublin 4, Ireland.
Muhammad R KhanDepartment of Medical Oncology, St. Vincent's University Hospital, Elm Park, Dublin 4, Ireland.
Paul SelvaduraiDepartment of Medical Oncology, St. Vincent's University Hospital, Elm Park, Dublin 4, Ireland.
John CrownDepartment of Medical Oncology, St. Vincent's University Hospital, Elm Park, Dublin 4, Ireland.
Raymond S McDermottDepartment of Medical Oncology, St. Vincent's University Hospital, Elm Park, Dublin 4, Ireland.
Janice M WalsheDepartment of Medical Oncology, St. Vincent's University Hospital, Elm Park, Dublin 4, Ireland.
David W FennellyDepartment of Medical Oncology, St. Vincent's University Hospital, Elm Park, Dublin 4, Ireland.
Emer O HanrahanDepartment of Medical Oncology, St. Vincent's University Hospital, Elm Park, Dublin 4, Ireland.
Mark DohertyDepartment of Medical Oncology, St. Vincent's University Hospital, Elm Park, Dublin 4, Ireland.
Michaela J HigginsDepartment of Medical Oncology, St. Vincent's University Hospital, Elm Park, Dublin 4, Ireland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundComprehensive geriatric assessment (CGA) is recommended by international guidelines prior to initiation of systemic anti-cancer treatment (SACT). In practice, CGA is limited by time constraints, lack of resources and expert interpretation.

aimsThe primary objective of this pilot study was to establish the prevalence of frailty (assessed by G8), cognitive impairment (assessed by Mini-Cog), and risk of chemotherapy toxicity (assessed by CARG Chemo-Toxicity Calculator) among patients (pts) ≥65 years commencing SACT. We selected these three screening tools due to the ease of conducting them in a busy outpatient setting. In addition, they have been validated to predict frailty and risk of toxicity from SACT among older adults with cancer.

methodsEligible participants were identified from medical oncology clinics. Assessments were conducted in an outpatient setting by treating physicians. Pt records were reviewed to gather demographic and cancer details. Statistical analyses were conducted using SPSS statistical software.

resultsSixty-three participants were enrolled. The mean age of participants was 73yrs (range=65-88). Thirty-three (52.4%) were female and 30 (47.6%) were male. The majority (n=38, 60.3%) had metastatic cancer. The mean G8 score was 11.9 (range=6-19). Eighty-three percent had a G8 score ≤14. Mini-Cog was positive in 13 pts (21%). The mean CARG score was 7.5 (range=0-16), and 80% had a risk of at least 50% grade ≥3 toxicity. Of these, 48 (76.2%) received chemotherapy and 15 (23.8%) received non-cytotoxic SACT. In multi-variate analyses, age, cancer type, treatment type, and disease stage did not impact G8, Mini-Cog, or CARG scores.

conclusionsOur study has several limitations but suggests that the majority of older adults with cancer would qualify for formal CGA assessment. The risk of high-grade toxicity from SACT is substantial in this cohort. Chronological age was not found to negatively impact pts' frailty, cognition, or risk of toxicity.

Indexed as

FrailtyNeoplasmsAgedAged, 80 and overCognitionEarly Detection of CancerFemaleGeriatric AssessmentHospitalsHumansIrelandMalePilot ProjectsChemotoxicityElderlyGeriatricOncologyScreening

Identifiers

PMID37450258

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