ArticleJournal of endocrinological investigation2024
Bone health and body composition in transgender adults before gender-affirming hormonal therapy: data from the COMET study.
Article in Journal of endocrinological investigation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Getting old in the desired gender: a systematic review on aging diseases in transgender people.Journal of endocrinological investigation · 2024Pooled it
- Body composition in male hypogonadism: practical considerations to the use of dual-energy x-ray absorptiometry.Reviews in endocrine & metabolic disorders · 2026Review
- Nutritional Monitoring During Gender-Affirming Hormone Therapy: Body Composition and Metabolic Implications.Nutrients · 2026Review
- Bone health in gender-diverse individuals: current challenges and future directions.Hormones (Athens, Greece) · 2026Review
- Impact of reference gender on bone mineral density and fracture risk assessment in transgender adults.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Observational
- Risk and management of congenital thrombophilia in transgender individuals undergoing gender-affirming hormone therapy.International journal of transgender health · 2026Article
- Age-dependent bone mineral density responses to gender-affirming hormone therapy in transgender individuals: a one-year prospective study.Journal of endocrinological investigation · 2025Observational
- Improving care for individuals with gender incongruence: Establishing a multidisciplinary approach in Italy.Journal of endocrinological investigation · 2025Article
- Physical activity behaviors in trans and gender diverse adults: a scoping review.International journal of transgender health · 2025Review
- Physical Activity, Anxiety, Depression, and Body Image in Trans Individuals: An Exploratory Study.Healthcare (Basel, Switzerland) · 2024Article
- Review
- Body composition and perceived stress levels in transgender individuals after one year of gender affirming hormone therapy.Frontiers in endocrinology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePreliminary data suggested that bone mineral density (BMD) in transgender adults before initiating gender-affirming hormone therapy (GAHT) is lower when compared to cisgender controls. In this study, we analyzed bone metabolism in a sample of transgender adults before GAHT, and its possible correlation with biochemical profile, body composition and lifestyle habits (i.e., tobacco smoke and physical activity).
methodsMedical data, smoking habits, phospho-calcic and hormonal blood tests and densitometric parameters were collected in a sample of 125 transgender adults, 78 Assigned Females At Birth (AFAB) and 47 Assigned Males At Birth (AMAB) before GAHT initiation and 146 cisgender controls (57 females and 89 males) matched by sex assigned at birth and age. 55 transgender and 46 cisgender controls also underwent a complete body composition evaluation and assessment of physical activity using the International Physical Activity Questionnaire (IPAQ).
results14.3% of transgender and 6.2% of cisgender sample, respectively, had z-score values < -2 (p = 0.04). We observed only lower vitamin D values in transgender sample regarding biochemical/hormonal profile. AFAB transgender people had more total fat mass, while AMAB transgender individuals had reduced total lean mass as compared to cisgender people (53.94 ± 7.74 vs 58.38 ± 6.91, p < 0.05). AFAB transgender adults were more likely to be active smokers and tend to spend more time indoor. Fat Mass Index (FMI) was correlated with lumbar and femur BMD both in transgender individuals, while no correlations were found between lean mass parameters and BMD in AMAB transgender people.
conclusionsBody composition and lifestyle factors could contribute to low BMD in transgender adults before GAHT.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.