Evidence map›Paper›PMID 37450039›Full record

ArticleCell and tissue research2023

BDNF alleviates Parkinson's disease by promoting STAT3 phosphorylation and regulating neuronal autophagy.

Xin Geng, Yanghong Zou, Jinghui Li, Shipeng Li, Renli Qi, Hualin Yu, Lianmei Zhong

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell and tissue research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 30 citations in OpenAlex.

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  6. Disruption of BDNF signalling in neuropathologies.Biochemical Society transactions · 2026
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  8. Neuroinflammation and Disease: Pathways and Opportunities.Annual review of pharmacology and toxicology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Xin Geng *The Second Department of Neurosurgery, The First Affiliated Hospital of Kunming Medical University, Yunnan Provincial Clinical Research Center for Neurological Disease, No. 295 Xichang Road, Kunming, Yunnan, 650032, China.
Yanghong Zou *The Second Department of Neurosurgery, The First Affiliated Hospital of Kunming Medical University, Yunnan Provincial Clinical Research Center for Neurological Disease, No. 295 Xichang Road, Kunming, Yunnan, 650032, China.
Jinghui LiThe Second Department of Neurosurgery, The First Affiliated Hospital of Kunming Medical University, Yunnan Provincial Clinical Research Center for Neurological Disease, No. 295 Xichang Road, Kunming, Yunnan, 650032, China.
Shipeng LiThe Second Department of Neurosurgery, The First Affiliated Hospital of Kunming Medical University, Yunnan Provincial Clinical Research Center for Neurological Disease, No. 295 Xichang Road, Kunming, Yunnan, 650032, China.
Renli QiThe Second Department of Neurosurgery, The First Affiliated Hospital of Kunming Medical University, Yunnan Provincial Clinical Research Center for Neurological Disease, No. 295 Xichang Road, Kunming, Yunnan, 650032, China.
Hualin YuThe Second Department of Neurosurgery, The First Affiliated Hospital of Kunming Medical University, Yunnan Provincial Clinical Research Center for Neurological Disease, No. 295 Xichang Road, Kunming, Yunnan, 650032, China. xuhl@ydyy.cn.ORCID http://orcid.org/0000-0002-1991-4422
Lianmei ZhongThe Second Department of Neurosurgery, The First Affiliated Hospital of Kunming Medical University, Yunnan Provincial Clinical Research Center for Neurological Disease, No. 295 Xichang Road, Kunming, Yunnan, 650032, China. 13888967787@163.com.
Kunming Medical University · CN

Funding

Associated Project of Yunnan Province Science & Technology Department and Kunming Medical University Basic Research for Application 202301AY070001-209Geng Xin, a Project for the Training of Technological Innovation Talents in Yunnan Province 202205AD160006PhD Research Fund of the First Affiliated Hospital of Kunming Medical University 2020BS019PhD Research Fund of the First Aiffliated Hospital of Kunming Medical University 2022BS015sub-project of the Special Fund for Applied Basic Research of The Center for Diagnosis and Treatment of Neurological Diseases in Yunnan Province ZX2019-03-05The Major Science and Technology Special Project of Yunnan Province 202102AA100061
6 · The paper itself

Abstract

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the gradual death of dopaminergic neurons. Brain-derived neurotrophic factor (BDNF) and its receptors are widely distributed throughout the central nervous system, which can promote the survival and growth of neurons and protect neurons. This study revealed that BDNF promotes STAT3 phosphorylation and regulates autophagy in neurons. The PD mouse model was established by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Moreover, SH-SY5Y cells were treated with 1-methyl-4-phenyl-pyridinium (MPP

Indexed as

NeuroblastomaNeuroprotective AgentsParkinson Disease1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnimalsAutophagyBrain-Derived Neurotrophic FactorDopaminergic NeuronsHumansMiceMice, Inbred C57BLPhosphatidylinositol 3-KinasesPhosphorylationSTAT3 Transcription Factor1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineBdnf protein, mouseBrain-Derived Neurotrophic FactorNeuroprotective AgentsPhosphatidylinositol 3-KinasesSTAT3 protein, humanSTAT3 Transcription FactorAutophagyBDNFParkinsonSTAT3 phosphorylation

Identifiers

PMID37450039
PMCPMC10485099
OpenAlexW4384340705

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.