Evidence map›Paper›PMID 37449844›Full record

ArticlemBio2023

Systemic host inflammation induces stage-specific transcriptomic modification and slower maturation in malaria parasites.

Lianne I M Lansink, Oliver P Skinner, Jessica A Engel, Hyun Jae Lee, Megan S F Soon, Cameron G Williams, Arya SheelaNair, Clara P S Pernold, Pawat Laohamonthonkul, Jasmin Akter and 12 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 9 institutions in 4 countries.

Lianne I M LansinkQIMR Berghofer Medical Research Institute , Herston, Brisbane, Queensland, Australia.
Oliver P SkinnerDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne , Parkville, Victoria, Australia.ORCID 0000-0003-0898-4131
Jessica A EngelQIMR Berghofer Medical Research Institute , Herston, Brisbane, Queensland, Australia.
Hyun Jae LeeDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne , Parkville, Victoria, Australia.
Megan S F SoonQIMR Berghofer Medical Research Institute , Herston, Brisbane, Queensland, Australia.
Cameron G WilliamsDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne , Parkville, Victoria, Australia.
Arya SheelaNairQIMR Berghofer Medical Research Institute , Herston, Brisbane, Queensland, Australia.
Clara P S PernoldQIMR Berghofer Medical Research Institute , Herston, Brisbane, Queensland, Australia.
Pawat LaohamonthonkulWalter and Eliza Hall Institute of Medical Research , Parkville, Victoria, Australia.
Jasmin AkterQIMR Berghofer Medical Research Institute , Herston, Brisbane, Queensland, Australia.
Thomas StollQIMR Berghofer Medical Research Institute , Herston, Brisbane, Queensland, Australia.
Michelle M HillQIMR Berghofer Medical Research Institute , Herston, Brisbane, Queensland, Australia.
Arthur M TalmanWellcome Sanger Institute, Wellcome Genome Campus , Hinxton, Cambridgeshire, United Kingdom.
Andrew RussellWellcome Sanger Institute, Wellcome Genome Campus , Hinxton, Cambridgeshire, United Kingdom.
Mara LawniczakWellcome Sanger Institute, Wellcome Genome Campus , Hinxton, Cambridgeshire, United Kingdom.
Xiaoxiao JiaDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne , Parkville, Victoria, Australia.
Brendon ChuaDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne , Parkville, Victoria, Australia.
Dovile AndersonMonash Institute of Pharmaceutical Sciences, Monash University , Parkville, Victoria, Australia.
Darren J CreekMonash Institute of Pharmaceutical Sciences, Monash University , Parkville, Victoria, Australia.ORCID 0000-0001-7497-7082
Miles P Davenport *The Kirby Institute, University of New South Wales , Kensington, Sydney, New South Wales, Australia.
David S Khoury *The Kirby Institute, University of New South Wales , Kensington, Sydney, New South Wales, Australia.ORCID 0000-0002-2663-1551
Ashraful Haque *Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne , Parkville, Victoria, Australia.ORCID 0000-0003-2260-0026
QIMR Berghofer Medical Research Institute · AUThe University of Melbourne · AUMonash University · AUUNSW Sydney · AUBroad Institute · USCentre National de la Recherche Scientifique · FRQueensland University of Technology · AUWalter and Eliza Hall Institute of Medical Research · AUWellcome Sanger Institute · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Maturation rates of malaria parasites within red blood cells (RBCs) can be influenced by host nutrient status and circadian rhythm; whether host inflammatory responses can also influence maturation remains less clear. Here, we observed that systemic host inflammation induced in mice by an innate immune stimulus, lipopolysaccharide (LPS), or by ongoing acute

Indexed as

MalariaParasitesAnimalsErythrocytesInflammationLipopolysaccharidesMiceTranscriptomeLipopolysaccharideshost inflammationhost-parasite interactionmalariametabolomicsparasite maturationPlasmodiumsingle-cell transcriptomics

Identifiers

PMID37449844
PMCPMC10470790
OpenAlexW4384339262

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.