Evidence map›Paper›PMID 37449562›Full record

ArticleJournal of the American Heart Association2023

Screening for Rare Coding Variants That Associate With the QTc Interval in Iceland.

Gardar Sveinbjornsson, Bara D Benediktsdottir, Gunnlaugur Sigfusson, Kristjan Norland, Olafur B Davidsson, Rosa B Thorolfsdottir, Vinicius Tragante, Gudny A Arnadottir, Brynjar O Jensson, Hildigunnur Katrinardottir and 12 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. A frameshift variant inEuropean heart journal. Case reports · 2026
    Article
  2. Mapping the Functional Landscape ofmedRxiv : the preprint server for health sciences · 2025
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 3 institutions in 1 country.

Gardar SveinbjornssondeCODE Genetics/Amgen, Inc. Reykjavik Iceland.ORCID 0000-0003-2429-9468
Bara D BenediktsdottirInternal Medicine, Landspitali-The National University Hospital of Iceland Reykjavik Iceland.
Gunnlaugur SigfussonChildren's Medical Center Landspítali-The National University Hospital of Iceland Reykjavík Iceland.
Kristjan NorlanddeCODE Genetics/Amgen, Inc. Reykjavik Iceland.
Olafur B DavidssondeCODE Genetics/Amgen, Inc. Reykjavik Iceland.ORCID 0000-0002-7226-5409
Rosa B ThorolfsdottirdeCODE Genetics/Amgen, Inc. Reykjavik Iceland.
Vinicius TragantedeCODE Genetics/Amgen, Inc. Reykjavik Iceland.ORCID 0000-0002-8223-8957
Gudny A ArnadottirdeCODE Genetics/Amgen, Inc. Reykjavik Iceland.ORCID 0000-0001-6571-423X
Brynjar O JenssondeCODE Genetics/Amgen, Inc. Reykjavik Iceland.
Hildigunnur KatrinardottirdeCODE Genetics/Amgen, Inc. Reykjavik Iceland.
Run FridriksdottirdeCODE Genetics/Amgen, Inc. Reykjavik Iceland.
Hallbera GudmundsdottirdeCODE Genetics/Amgen, Inc. Reykjavik Iceland.
Hildur M AegisdottirdeCODE Genetics/Amgen, Inc. Reykjavik Iceland.
Brynjar FridrikssonThe Capital District Fire and Rescue Service Reykjavik Iceland.
Gudmundur ThorgeirssondeCODE Genetics/Amgen, Inc. Reykjavik Iceland.ORCID 0000-0002-7146-1395
Vidar MagnussonThe Capital District Fire and Rescue Service Reykjavik Iceland.
Asmundur OddssondeCODE Genetics/Amgen, Inc. Reykjavik Iceland.ORCID 0000-0002-4606-5163
Patrick SulemdeCODE Genetics/Amgen, Inc. Reykjavik Iceland.ORCID 0000-0001-7123-6123
Daniel F GudbjartssondeCODE Genetics/Amgen, Inc. Reykjavik Iceland.
Hilma HolmdeCODE Genetics/Amgen, Inc. Reykjavik Iceland.ORCID 0000-0002-9517-6636
David O ArnardeCODE Genetics/Amgen, Inc. Reykjavik Iceland.ORCID 0000-0002-9442-1644
Kari StefanssondeCODE Genetics/Amgen, Inc. Reykjavik Iceland.
deCODE Genetics (Iceland) · ISNational University Hospital of Iceland · ISInnovation Center Iceland · IS

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Long-QT syndrome (LQTS) is a cardiac repolarization abnormality that can lead to sudden cardiac death. The most common causes are rare coding variants in the genes

Indexed as

KCNQ1 Potassium ChannelLong QT SyndromeDeath, Sudden, CardiacElectrocardiographyHumansIcelandMutationKCNQ1 Potassium Channelgenetic epidemiologygeneticslong‐QT syndromeprecision medicine

Identifiers

PMID37449562
PMCPMC10382112
OpenAlexW4384300603

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.