Evidence map›Paper›PMID 37449457›Full record

ArticleGlia2023

Microglial depletion after brain injury prolongs inflammation and impairs brain repair, adult neurogenesis and pro-regenerative signaling.

Kanagaraj Palsamy, Jessica Y Chen, Kaia Skaggs, Yusuf Qadeer, Meghan Connors, Noah Cutler, Joshua Richmond, Vineeth Kommidi, Allison Poles, Danielle Affrunti and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Glia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Macrophages Mediate Mesoscale Brain Mechanical Homeostasis.Advanced materials (Deerfield Beach, Fla.) · 2026
    Article
  5. Article
  6. Review
  7. Review
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Kanagaraj PalsamyDepartment of Neurology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0001-8059-589X
Jessica Y ChenDepartment of Neurology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-4833-6756
Kaia SkaggsDepartment of Neurology, University of Michigan, Ann Arbor, Michigan, USA.
Yusuf QadeerDepartment of Neurology, University of Michigan, Ann Arbor, Michigan, USA.
Meghan ConnorsDepartment of Neurology, University of Michigan, Ann Arbor, Michigan, USA.
Noah CutlerDepartment of Neurology, University of Michigan, Ann Arbor, Michigan, USA.
Joshua RichmondDepartment of Neurology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0001-8579-6818
Vineeth KommidiDepartment of Neurology, University of Michigan, Ann Arbor, Michigan, USA.
Allison PolesDepartment of Neurology, University of Michigan, Ann Arbor, Michigan, USA.
Danielle AffruntiDepartment of Neurology, University of Michigan, Ann Arbor, Michigan, USA.
Curtis PowellMichigan Neuroscience Institute, Ann Arbor, Michigan, USA.
Daniel GoldmanMichigan Neuroscience Institute, Ann Arbor, Michigan, USA.ORCID 0000-0002-0013-1188
Jack M ParentDepartment of Neurology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-2972-1528
University of Michigan · USUniversity of Findlay · US

Funding

PREDOCTORAL TRAINING IN GENETICST32GM007544 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MORAN, JOHN V. · 1985 to 2022
$11.3M
Mechanisms underlying Muller glia’s regenerative potentialR01EY032867 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GOLDMAN, DANIEL J · 2021 to 2025
$1.9M
Zebrafish Models to Study Adult Forebrain NeurogenesisR21NS061293 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PARENT, JACK M · 2008 to 2009
$355k
NEI NIH HHS R01 EY032867NIGMS NIH HHS T32 GM007544NINDS NIH HHS R21 NS061293
6 · The paper itself

Abstract

The adult zebrafish brain, unlike mammals, has a remarkable regenerative capacity. Although inflammation in part hinders regeneration in mammals, it is necessary for zebrafish brain repair. Microglia are resident brain immune cells that regulate the inflammatory response. To explore the microglial role in repair, we used liposomal clodronate or colony stimulating factor-1 receptor (csf1r) inhibitor to suppress microglia after brain injury, and also examined regeneration in two genetic mutant lines that lack microglia. We found that microglial ablation impaired telencephalic regeneration after injury. Microglial suppression attenuated cell proliferation at the intermediate progenitor cell amplification stage of neurogenesis. Notably, the loss of microglia impaired phospho-Stat3 (signal transducer and activator of transcription 3) and ß-Catenin signaling after injury. Furthermore, the ectopic activation of Stat3 and ß-Catenin rescued neurogenesis defects caused by microglial loss. Microglial suppression also prolonged the post-injury inflammatory phase characterized by neutrophil accumulation, likely hindering the resolution of inflammation. These findings reveal specific roles of microglia and inflammatory signaling during zebrafish telencephalic regeneration that should advance strategies to improve mammalian brain repair.

Indexed as

Brain InjuriesMicrogliaAnimalsBrainCateninsInflammationMammalsNeurogenesisZebrafishCateninsbrain injurymicrogliaradial gliaregenerationzebrafish

Identifiers

PMID37449457
PMCPMC10528132
OpenAlexW4384300103

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.