ArticleCirculation research2023
Loss of the Atrial Fibrillation-Related Gene,
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Article in Circulation research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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28citing papers in PubMed, 1 pooled it
5.8field-weighted citation impact, top 3% of its field
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Cross-population GWAS and proteomics improve risk prediction and reveal mechanisms in atrial fibrillation.Nature communications · 2025Pooled it
- Shared Genetics of Kidney Function Traits and Bladder Cancer: A Genome-Wide Cross-Trait Analysis.Cancer medicine · 2026Article
- Monogenic Syndromes as a Cause of Adverse Drug Reactions in the Russian Population.International journal of molecular sciences · 2026Article
- The cardiac conduction system: development, function and therapeutic targets.Nature reviews. Cardiology · 2026Review
- An epigenomic investigation of atrial fibrillation in a matched left and right atrial human cohort.Clinical epigenetics · 2026Article
- A reduced TBX5-dependent gene regulatory network links atrial fibrillation and heart failure.Nature cardiovascular research · 2026Article
- Integrative transcriptomic and structural analysis identifies PTGS2 as a key target in ischemic stroke associated with neuroinflammation.Molecular diversity · 2026Article
- Association of Gene Polymorphism at Atrial Fibrillation in the Kazakh Population: Case-Control Study.Genes · 2026Article
- Advances in genetics and multi-omics for ischemic stroke: from pathogenesis to clinical translation.Frontiers in genetics · 2026Review
- Discovery ofDiagnostics (Basel, Switzerland) · 2025Article
- Targeted nanodelivery strategies for atrial fibrillation: concomitant targeting of fibrosis suppression and electrical conduction restoration through advanced nanobiotechnology.Journal of nanobiotechnology · 2025Review
- Epigenome-wide profiling of trisomy 18 specific DNA methylation signatures in first-trimester chorionic villi.Clinical epigenetics · 2025Article
- Arrhythmia-Induced Cardiomyopathy in Atrial Fibrillation: Pathogenesis, Diagnosis, and Treatment.Life (Basel, Switzerland) · 2025Review
- ZFHX3 Knockdown Enhances Metabolic Distress in Atrial Myocytes Through Mitochondrial and Calcium Dysregulation: Mitigation by Trimetazidine.International journal of molecular sciences · 2025Article
- Dissecting cardiovascular disease-associated noncoding genetic variants using human iPSC models.Stem cell reports · 2025Review
- Polygenic Risk and Cardiovascular Event Risk in Patients With Atrial Fibrillation With Low to Intermediate Stroke Risk.Journal of the American Heart Association · 2025Article
- Relationship between the expression of striated preferentially expressed gene (Journal of thoracic disease · 2025Article
- Article
- 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2025Review
- The Role of Somatic Mutations in Ischemic Stroke: CHIP's Impact on Vascular Health.Neurology international · 2025Review
Corrections and comments
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Authors and funding
18 authors at 5 institutions in 7 countries.
Heather S Jameson *Cardiovascular Research Center (H.S.J., A.H., M.C.H., L.X., J.Y., A.B., E.R., A.W.H., W.J.H., S.C., M.B., E.S., J.A.M., R.W.M., P.T.E.), Massachusetts General Hospital, Boston.
Alan Hanley *Cardiovascular Research Center (H.S.J., A.H., M.C.H., L.X., J.Y., A.B., E.R., A.W.H., W.J.H., S.C., M.B., E.S., J.A.M., R.W.M., P.T.E.), Massachusetts General Hospital, Boston.
Matthew C HillCardiovascular Research Center (H.S.J., A.H., M.C.H., L.X., J.Y., A.B., E.R., A.W.H., W.J.H., S.C., M.B., E.S., J.A.M., R.W.M., P.T.E.), Massachusetts General Hospital, Boston.ORCID 0000-0003-4578-3873
Ling XiaoCardiovascular Research Center (H.S.J., A.H., M.C.H., L.X., J.Y., A.B., E.R., A.W.H., W.J.H., S.C., M.B., E.S., J.A.M., R.W.M., P.T.E.), Massachusetts General Hospital, Boston.ORCID 0000-0002-5463-5576
Jiangchuan YeCardiovascular Research Center (H.S.J., A.H., M.C.H., L.X., J.Y., A.B., E.R., A.W.H., W.J.H., S.C., M.B., E.S., J.A.M., R.W.M., P.T.E.), Massachusetts General Hospital, Boston.
Aneesh BapatCardiovascular Research Center (H.S.J., A.H., M.C.H., L.X., J.Y., A.B., E.R., A.W.H., W.J.H., S.C., M.B., E.S., J.A.M., R.W.M., P.T.E.), Massachusetts General Hospital, Boston.ORCID 0000-0002-1996-522X
Elsa RonzierCardiovascular Research Center (H.S.J., A.H., M.C.H., L.X., J.Y., A.B., E.R., A.W.H., W.J.H., S.C., M.B., E.S., J.A.M., R.W.M., P.T.E.), Massachusetts General Hospital, Boston.ORCID 0000-0003-1008-4271
Amelia Weber HallCardiovascular Research Center (H.S.J., A.H., M.C.H., L.X., J.Y., A.B., E.R., A.W.H., W.J.H., S.C., M.B., E.S., J.A.M., R.W.M., P.T.E.), Massachusetts General Hospital, Boston.ORCID 0000-0002-7915-0313
William J HuckerCardiovascular Research Center (H.S.J., A.H., M.C.H., L.X., J.Y., A.B., E.R., A.W.H., W.J.H., S.C., M.B., E.S., J.A.M., R.W.M., P.T.E.), Massachusetts General Hospital, Boston.ORCID 0000-0002-4703-0579
Sebastian ClaussCardiovascular Research Center (H.S.J., A.H., M.C.H., L.X., J.Y., A.B., E.R., A.W.H., W.J.H., S.C., M.B., E.S., J.A.M., R.W.M., P.T.E.), Massachusetts General Hospital, Boston.ORCID 0000-0002-5675-6128
Miranda BarazzaCardiovascular Research Center (H.S.J., A.H., M.C.H., L.X., J.Y., A.B., E.R., A.W.H., W.J.H., S.C., M.B., E.S., J.A.M., R.W.M., P.T.E.), Massachusetts General Hospital, Boston.ORCID 0000-0002-2590-2081
Elizabeth SilberCardiovascular Research Center (H.S.J., A.H., M.C.H., L.X., J.Y., A.B., E.R., A.W.H., W.J.H., S.C., M.B., E.S., J.A.M., R.W.M., P.T.E.), Massachusetts General Hospital, Boston.
Julie A MinaCardiovascular Research Center (H.S.J., A.H., M.C.H., L.X., J.Y., A.B., E.R., A.W.H., W.J.H., S.C., M.B., E.S., J.A.M., R.W.M., P.T.E.), Massachusetts General Hospital, Boston.
Nathan R TuckerMasonic Medical Research Institute, Utica, NY (N.R.T.).ORCID 0000-0002-5071-4218
Robert W MillsCardiovascular Research Center (H.S.J., A.H., M.C.H., L.X., J.Y., A.B., E.R., A.W.H., W.J.H., S.C., M.B., E.S., J.A.M., R.W.M., P.T.E.), Massachusetts General Hospital, Boston.
Jin-Tang DongDepartment of Human Cell Biology and Genetics, Southern University of Science and Technology School of Medicine, Shenzhen, China (J.-T.D.).ORCID 0000-0003-2349-5782
David J MilanLeducq Foundation, Boston, MA (D.J.M.).ORCID 0000-0003-0149-3110
Patrick T EllinorCardiovascular Research Center (H.S.J., A.H., M.C.H., L.X., J.Y., A.B., E.R., A.W.H., W.J.H., S.C., M.B., E.S., J.A.M., R.W.M., P.T.E.), Massachusetts General Hospital, Boston.ORCID 0000-0002-2067-0533
MACOM (United States) · USBroad Institute · USFondation Leducq · FRMasonic Medical Research Laboratory · USSouthern University of Science and Technology · CN
Funding
IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVALR01HL092577 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BENJAMIN, EMELIA J., ELLINOR, PATRICK THOMAS · 2009 to 2025
$20.6MMULTIDISCIPLINARY RESEARCH TRAINING IN CARDIOLOGYT32HL007208 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Patrick Thomas Ellinor, David E Sosnovik · 1985 to 2026
$16.1MGenomics of Cardiac ArrhythmiasR01HL139731 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ELLINOR, PATRICK THOMAS · 2018 to 2022
$3.3MUsing Electrocardiogram Genetics to Inform Arrhythmia RiskR01HL157635 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ELLINOR, PATRICK THOMAS, MIRSHAHI, TOORAJ · 2022 to 2025
$2.9MDefining the functional variation underlying atrial fibrillation riskK01HL140187 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI TUCKER, NATHAN R · 2018 to 2022
$858kNHLBI NIH HHS K01 HL140187NHLBI NIH HHS R01 HL092577NHLBI NIH HHS R01 HL139731NHLBI NIH HHS R01 HL157635NHLBI NIH HHS T32 HL007208
Abstract
background
methodsCRISPR-Cas9 genome editing, chromatin immunoprecipitation, and luciferase assays in pluripotent stem cell-derived cardiomyocytes were used to identify causative genetic variation related to AF at the
resultsWe found single-nucleotide polymorphism (SNP) rs12931021 modulates an enhancer regulating
conclusionsOur findings implicate
Indexed as
Atrial FibrillationHomeodomain ProteinsAnimalsCalciumDilatationHumansMiceMyocytes, CardiacTranscription FactorsCalciumHomeodomain ProteinsTranscription FactorsZFHX3 protein, humanZfhx3 protein, mouseatrial fibrillationelectrophysiologymicemyocytes, cardiactranscription factors
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.