Evidence map›Paper›PMID 37449271›Full record

ArticleFrontiers in neuroscience2023

Modeling Alzheimer's disease related phenotypes in the Ts65Dn mouse: impact of age on Aβ, Tau, pTau, NfL, and behavior.

Cassia Overk, Emma Fiorini, Chiara Babolin, Marija Vukicevic, Catherine Morici, Rime Madani, Valerie Eligert, Marie Kosco-Vilbois, Amanda Roberts, Ann Becker and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Cassia OverkDepartment of Neurosciences, University of California, San Diego, La Jolla, CA, United States.
Emma FioriniAC Immune SA, Lausanne, Switzerland.
Chiara BabolinAC Immune SA, Lausanne, Switzerland.
Marija VukicevicAC Immune SA, Lausanne, Switzerland.
Catherine MoriciAC Immune SA, Lausanne, Switzerland.
Rime MadaniAC Immune SA, Lausanne, Switzerland.
Valerie EligertAC Immune SA, Lausanne, Switzerland.
Marie Kosco-VilboisAC Immune SA, Lausanne, Switzerland.
Amanda RobertsAnimal Models Core Facility, The Scripps Research Institute, La Jolla, CA, United States.
Ann BeckerDepartment of Neurosciences, University of California, San Diego, La Jolla, CA, United States.
Andrea PfeiferAC Immune SA, Lausanne, Switzerland.
William C MobleyDepartment of Neurosciences, University of California, San Diego, La Jolla, CA, United States.
AC Immune (Switzerland) · CHUniversity of California San Diego · USScripps Research Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: People with DS are highly predisposed to Alzheimer's disease (AD) and demonstrate very similar clinical and pathological features. Ts65Dn mice are widely used and serve as the best-characterized animal model of DS. Methods: We undertook studies to characterize age-related changes for AD-relevant markers linked to Aβ, Tau, and phospho-Tau, axonal structure, inflammation, and behavior. Results: We found age related changes in both Ts65Dn and 2N mice. Relative to 2N mice, Ts65Dn mice showed consistent increases in Aβ40, insoluble phospho-Tau, and neurofilament light protein. These changes were correlated with deficits in learning and memory. Discussion: These data have implications for planning future experiments aimed at preventing disease-related phenotypes and biomarkers. Interventions should be planned to address specific manifestations using treatments and treatment durations adequate to engage targets to prevent the emergence of phenotypes.

Indexed as

AbetaageAlzheimer’s diseaseanimal modelbehaviorDown syndromeDS-ADtau

Identifiers

PMID37449271
PMCPMC10336548
OpenAlexW4382399631

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.