Evidence map›Paper›PMID 37449098›Full record

ArticleHeliyon2023

Calpeptin may reverse glucocorticoid-resistance of allergic rhinitis associated with cigarette smoke exposure by down-regulating interferon regulatory factor 1.

Wen-Xuan Zhu, Yang Xi, Fen Li, Wo-Er Jiao, Zi-Jing Li, Shi-Ming Chen, Yong-Gang Kong, Yu Xu, Yu-Qin Deng, Jing-Jing Zuo and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Wen-Xuan ZhuDepartment of Otolaryngology, Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, PR China.
Yang XiDepartment of Otolaryngology, Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, PR China.
Fen LiInstitute of Otolaryngology, Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, PR China.
Wo-Er JiaoDepartment of Otolaryngology, Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, PR China.
Zi-Jing LiDepartment of Otolaryngology, Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, PR China.
Shi-Ming ChenDepartment of Otolaryngology, Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, PR China.
Yong-Gang KongDepartment of Otolaryngology, Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, PR China.
Yu XuDepartment of Otolaryngology, Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, PR China.
Yu-Qin DengDepartment of Rhinology and Allergy, Renmin Hospital of Wuhan University, Wuhan, PR China.
Jing-Jing ZuoDepartment of Otolaryngology, Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, PR China.
Ze-Zhang TaoDepartment of Otolaryngology, Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, PR China.
Wuhan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cigarette smoke exposure is an important factor in chronic inflammation in patients with allergic rhinitis (AR); however, the relationship between cigarette smoke and AR-related glucocorticoid resistance requires further study. In mice, calpeptin significantly reduces inflammation of the lower respiratory tract caused by cigarette smoke, but whether it can treat glucocorticoid-resistant AR caused by cigarette smoke requires further research. In this study, we confirmed that cigarette smoke exposure can aggravate the Th2 inflammatory response in AR leading to glucocorticoid resistance. The underlying mechanism may be related to decreased expression of DNA methyltransferase 3a (Dnmt3a), and increased expression of interferon regulatory factor 1 (IRF1). In addition, we found that calpeptin can inhibit the expression of IRF1 and thus treat AR-associated glucocorticoid resistance in rats exposed to cigarette smoke. These data suggest that calpeptin may downregulate IRF1 and therefore treat glucocorticoid resistance in AR-associated with cigarette smoke exposure.

Indexed as

Allergic rhinitisCalpeptinCigarette smokeGlucocorticoid resistanceRatsRegulatory factor 1

Identifiers

PMID37449098
PMCPMC10336445
OpenAlexW4380988198

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.