Evidence map›Paper›PMID 37448966›Full record

ArticleFrontiers in pharmacology2023

Dalbavancin as suppressive antibiotic therapy in patients with prosthetic infections: efficacy and safety.

Andrés Ruiz-Sancho, María Núñez-Núñez, Laura Castelo-Corral, Francisco Javier Martínez-Marcos, Nagore Lois-Martínez, Mohd Hafiz Abdul-Aziz, David Vinuesa-García

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 20 citations in OpenAlex.

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  12. Dalbavancin as suppressive therapy for implant-related infections: a case series with therapeutic drug monitoring and review of the literature.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 2 countries.

Andrés Ruiz-SanchoInfectious Diseases Department, University Hospital Clinico San Cecilio, Granada, Spain.
María Núñez-NúñezBiosanitary Research Institute, Ibs Granada, Granada, Spain.
Laura Castelo-CorralInfectious Diseases Department, University Hospital Complexo A Coruña, A Coruña, Spain.
Francisco Javier Martínez-MarcosInfectious Diseases Department, Juan Ramón Jiménez Hospital, Huelva, Spain.
Nagore Lois-MartínezInfectious Diseases Department, Severo Ochoa Hospital, Madrid, Spain.
Mohd Hafiz Abdul-AzizUniversity of Queensland Centre for Clinical Research (UQCCR), Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.
David Vinuesa-GarcíaInfectious Diseases Department, University Hospital Clinico San Cecilio, Granada, Spain.
Instituto de Investigación Biosanitaria de Granada · ESCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública · ESHospital Juan Ramón Jiménez · ESHospital Universitario Severo Ochoa · ESThe University of Queensland · AUUniversidade da Coruña · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Suppressive antibiotic therapy (SAT) is a strategy to alleviate symptoms and/or to reduce the progression of an infection when other treatment options cannot be used. Dalbavancin, due to its prolonged half-life, enables (bi) weekly dosing. Here, we report our multicenter real-life clinical experience with dalbavancin used as SAT in patients with prosthetic joint or vascular infections. Medical records of all adult patients with documented vascular or orthopedic chronic prosthetic infections, who received dalbavancin as SAT between 2016 and 2018 from four Spanish hospitals were reviewed for inclusion. Descriptive analysis of demographic characteristics, Charlson Comorbidity index, Barthel index, isolated pathogens and indication, concomitant antibiotic use, adverse events, and clinical outcome of SAT were performed. Eight patients were eligible for inclusion, where six patients had prosthetic vascular infections (aortic valve) and two patients had knee prosthetic joint infections. The most common pathogens were

Indexed as

antimicrobialsantimicrobial stewardshipdalbavancinGram-positive prosthetic infectionsuppressive antibiotic therapy

Identifiers

PMID37448966
PMCPMC10337584
OpenAlexW4382583746

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.