Evidence map›Paper›PMID 37448813›Full record

ArticleBioinformatics advances2023

BERTwalk for integrating gene networks to predict gene- to pathway-level properties.

Rami Nasser, Roded Sharan

Abstract read
In one paragraph

Article in Bioinformatics advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Heterogeneous network approaches to protein pathway prediction.Computational and structural biotechnology journal · 2024
    Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Rami NasserSchool of Computer Science, Tel Aviv University, Tel Aviv 69978, Israel.ORCID https://orcid.org/0000-0003-2670-6856
Roded SharanSchool of Computer Science, Tel Aviv University, Tel Aviv 69978, Israel.ORCID https://orcid.org/0000-0001-8363-4882

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Motivation: Graph representation learning is a fundamental problem in the field of data science with applications to integrative analysis of biological networks. Previous work in this domain was mostly limited to shallow representation techniques. A recent deep representation technique, BIONIC, has achieved state-of-the-art results in a variety of tasks but used arbitrarily defined components. Results: Here, we present BERTwalk, an unsupervised learning scheme that combines the BERT masked language model with a network propagation regularization for graph representation learning. The transformation from networks to texts allows our method to naturally integrate different networks and provide features that inform not only nodes or edges but also pathway-level properties. We show that our BERTwalk model outperforms BIONIC, as well as four other recent methods, on two comprehensive benchmarks in yeast and human. We further show that our model can be utilized to infer functional pathways and their effects. Availability and implementation: Code and data are available at https://github.com/raminass/BERTwalk. Contact: roded@tauex.tau.ac.il.

Identifiers

PMID37448813
PMCPMC10336298

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.