Evidence map›Paper›PMID 37448804›Full record

ArticleFrontiers in medicine2023

Baricitinib retention rate: 'real-life' data from a mono-centric cohort of patients affected by rheumatoid arthritis.

Caterina Baldi, Virginia Berlengiero, Paolo Falsetti, Alessandra Cartocci, Edoardo Conticini, Roberto D'Alessandro, Emilio D'Ignazio, Marco Bardelli, Marta Fabbroni, Luca Cantarini and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Observational
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Caterina BaldiRheumatology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.
Virginia BerlengieroRheumatology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.
Paolo FalsettiRheumatology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.
Alessandra CartocciDepartment of Medical Biotechnologies, University of Siena, Siena, Italy.
Edoardo ConticiniRheumatology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.
Roberto D'AlessandroRheumatology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.
Emilio D'IgnazioRheumatology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.
Marco BardelliRheumatology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.
Marta FabbroniRheumatology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.
Luca CantariniRheumatology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.
Bruno FredianiRheumatology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.
Stefano GentileschiRheumatology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.
University of Siena · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: The aim of this retrospective study was to evaluate baricitinib retention rate in patients affected by rheumatoid arthritis. Secondary aims were to compare the impact on treatment persistence of monotherapy and other variables such as systemic corticosteroid use, line of treatment, disease duration, sex, biomarkers positivity, and Herpes Zoster virus infection. Materials and methods: Patients with Rheumatoid Arthritis undergoing baricitinib were consecutively enrolled. Rheumatoid Arthritis diagnosis was performed with 2010 ACR/EULAR classification criteria. The cohort's demographic, clinical and therapeutical data were retrospectively collected. The whole follow-up duration was 104 weeks. Results: Ninety-five patients affected by rheumatoid arthritis and treated with baricitinib were consecutively enrolled. At the end of follow-up, the overall retention rate was 69.3%. No statistically significant difference in retention rate was observed between patients treated with baricitinib in monotherapy or in combination with methotrexate ( Conclusion: Our data show a good baricitinib retention rate after 12 and 24 months of observation (75.1 and 69.3%, respectively). In our cohort, concomitant treatment with methotrexate did not influence treatment persistence while retention was reduced in patients undergoing a steroidal treatment and/or in multi-failure subjects.

Indexed as

baricitinibJAK inhibitorsreal-liferetention raterheumatoid arthritistreatment

Identifiers

PMID37448804
PMCPMC10336222
OpenAlexW4382400588

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.