Evidence map›Paper›PMID 37448744›Full record

ArticleFrontiers in neurology2023

Combining high dose therapy, bilateral motor priming, and vagus nerve stimulation to treat the hemiparetic upper limb in chronic stroke survivors: a perspective on enhancing recovery.

Erin C King, Elizabeth Pedi, Mary Ellen Stoykov, Daniel M Corcos, Sebastian Urday

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Spinal Cord Stimulation Improves Feedback Control of Reaching Post-Stroke.medRxiv : the preprint server for health sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Erin C KingNorthwestern University, Evanston, IL, United States.
Elizabeth PediPhysical Therapy & Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
Mary Ellen StoykovShirley Ryan AbilityLab, Chicago, IL, United States.
Daniel M CorcosPhysical Therapy & Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
Sebastian UrdayThe Ken & Ruth Davee Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
Northwestern University · USShirley Ryan AbilityLab · US

Funding

Research Training in Sensorimotor NeurorehabilitationT32HD101395 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HECKMAN, CHARLES · 2021 to 2025
$1.7M
Bilateral Priming Plus Task Specific Training for Severe Upper Limb HemiparesisR01HD091492 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CORCOS, DANIEL M. · 2017 to 2021
$1.5M
Effects of Bilateral Motor Priming and Task Specific Training on Corticomotor Excitability and Transcallosal Inhibition in People with Upper Limb Hemiparesis Secondary to StrokeF31HD111318 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KING, ERIN · 2023 to 2024
$88k
NICHD NIH HHS F31 HD111318NICHD NIH HHS R01 HD091492NICHD NIH HHS T32 HD101395
6 · The paper itself

Abstract

Stroke is a leading cause of disability worldwide and upper limb hemiparesis is the most common post-stroke disability. Recent studies suggest that clinically significant motor recovery is possible in chronic stroke survivors with severe impairment of the upper limb. Three promising strategies that have been investigated are (1) high dose rehabilitation therapy (2) bilateral motor priming and (3) vagus nerve stimulation. We propose that the future of effective and efficient upper limb rehabilitation will likely require a combination of these approaches.

Indexed as

primingrehabilitationstroketask specific trainingvagus nerve stimulation

Identifiers

PMID37448744
PMCPMC10336216
OpenAlexW4382400396

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.