ArticleFrontiers in human neuroscience2023
Cytoarchitectonic mapping of the human frontal operculum-New correlates for a variety of brain functions.
Article in Frontiers in human neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.
- Ictal semiology in fronto-opercular epilepsy: A systematic review.Epileptic disorders : international epilepsy journal with videotape · 2026Pooled it
- Engagement of the speech motor system in challenging speech perception: Activation likelihood estimation meta-analyses.Human brain mapping · 2024Pooled it
- Investigating the effect of increased dopamine signaling on cerebral blood flow in Major Depressive Disorder: a double-blind randomized placebo-controlled study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Trial
- Escitalopram promotes recovery from hand paresis in cortical sensori-motor stroke: a randomized, double-blind, placebo-controlled longitudinal study.Journal of neuroengineering and rehabilitation · 2026Trial
- Unified Brain Mechanisms Underlying the Processing of Word Order Permutations of Arguments and Adjuncts in Sentences.Human brain mapping · 2026Article
- Individual differences in the effects of musical familiarity and musical features on brain activity during relaxation.Cognitive, affective & behavioral neuroscience · 2026Article
- Gateway to Syntax: On the Neural Origins of the Left Anterior Negativity and Their Functional Implications.Neurobiology of language (Cambridge, Mass.) · 2026Article
- The prefrontal operculum, a human-specific hub for the cognitive control of speech.Communications biology · 2025Article
- Deciphering the functional role of insular cortex stratification in trigeminal neuropathic pain.The journal of headache and pain · 2024Review
- Human intraparietal sulcal morphology relates to individual differences in language and memory performance.Communications biology · 2024Article
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Authors and funding
9 authors at 4 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The human frontal operculum (FOp) is a brain region that covers parts of the ventral frontal cortex next to the insula. Functional imaging studies showed activations in this region in tasks related to language, somatosensory, and cognitive functions. While the precise cytoarchitectonic areas that correlate to these processes have not yet been revealed, earlier receptorarchitectonic analysis resulted in a detailed parcellation of the FOp. We complemented this analysis by a cytoarchitectonic study of a sample of ten postmortem brains and mapped the posterior FOp in serial, cell-body stained histological sections using image analysis and multivariate statistics. Three new areas were identified: Op5 represents the most posterior area, followed by Op6 and the most anterior region Op7. Areas Op5-Op7 approach the insula, up to the circular sulcus. Area 44 of Broca's region, the most ventral part of premotor area 6, and parts of the parietal operculum are dorso-laterally adjacent to Op5-Op7. The areas did not show any interhemispheric or sex differences. Three-dimensional probability maps and a maximum probability map were generated in stereotaxic space, and then used, in a first proof-of-concept-study, for functional decoding and analysis of structural and functional connectivity. Functional decoding revealed different profiles of cytoarchitectonically identified Op5-Op7. While left Op6 was active in music cognition, right Op5 was involved in chewing/swallowing and sexual processing. Both areas showed activation during the exercise of isometric force in muscles. An involvement in the coordination of flexion/extension could be shown for the right Op6. Meta-analytic connectivity modeling revealed various functional connections of the FOp areas within motor and somatosensory networks, with the most evident connection with the music/language network for Op6 left. The new cytoarchitectonic maps are part of Julich-Brain, and publicly available to serve as a basis for future analyses of structural-functional relationships in this region.
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