Evidence map›Paper›PMID 37448595›Full record

ArticleMolecular therapy. Methods & clinical development2023

A method for polyclonal antigen-specific T cell-targeted genome editing (TarGET) for adoptive cell transfer applications.

Darya Palianina, Raphaël B Di Roberto, Rocío Castellanos-Rueda, Fabrice Schlatter, Sai T Reddy, Nina Khanna

Open access · goldAbstract read
In one paragraph

Article in Molecular therapy. Methods & clinical development, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
  3. From concept to cure: The evolution of CAR-T cell therapy.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Darya PalianinaDepartment of Biomedicine, University and University Hospital of Basel, 4056 Basel, Switzerland.
Raphaël B Di RobertoDepartment of Biosystems Science and Engineering, ETH Zürich, 4058 Basel, Switzerland.
Rocío Castellanos-RuedaDepartment of Biosystems Science and Engineering, ETH Zürich, 4058 Basel, Switzerland.
Fabrice SchlatterDepartment of Biosystems Science and Engineering, ETH Zürich, 4058 Basel, Switzerland.
Sai T ReddyDepartment of Biosystems Science and Engineering, ETH Zürich, 4058 Basel, Switzerland.
Nina KhannaDepartment of Biomedicine, University and University Hospital of Basel, 4056 Basel, Switzerland.
ETH Zurich · CHUniversity Hospital of Basel · CHUniversity of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adoptive cell therapy of donor-derived, antigen-specific T cells expressing native T cell receptors (TCRs) is a powerful strategy to fight viral infections in immunocompromised patients. Determining the fate of T cells following patient infusion hinges on the ability to track them

Indexed as

CRISPR-Cas9cytotoxic T cellsdeep sequencingEBVgenome editinglineage tracingscRNA-seqT cell therapyTCR sequencingvirus-specific T cells

Identifiers

PMID37448595
PMCPMC10336339
OpenAlexW4381248721

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.