Observational studyInfection control and hospital epidemiology2024
An outbreak investigation of parechovirus-A3 in a newborn nursery.
Observational study in Infection control and hospital epidemiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 3 citations in OpenAlex.
- Healthcare-associated parechovirus-A infection in hospitals with neonatal units in Japan: a nationwide survey.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2026Article
- Differences in Clinical Manifestations of Human Parechovirus-Related Meningitis in Neonates After the COVID-19 Pandemic: A Single-Center Exploratory Study.International journal of pediatrics · 2026Article
- Case Report: Preserved umbilical cords underscore family histories of inborn errors of immunity.Frontiers in immunology · 2025Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate parechovirus-A3 (PeV-A3) transmission in a newborn nursery, after encountering 3 neonates with fever and rash.
designAn observational study.
settingAt a newborn nursery at the general hospital in Hyogo, Japan.
participantsSymptomatic neonates and their family members, and asymptomatic neonates born during the same period.
methodsPCR assays for PeV-A and genotyping were used for the investigation of PeV-A3. Preserved umbilical cords were used to identify the route of transmission.
resultsPeV-A3 infection was confirmed in the three symptomatic neonates. The index case had fever and rash, and the 2 neonates treated later became symptomatic and had serum, cerebrospinal fluid, and stool specimens that were positive for PeV-A3 on PCR. The umbilical cord of the index case was positive for PeV-A3 on PCR. The family members of the index case, including the mother, were asymptomatic before delivery. The older sister and cousin of the PeV-A3-infected neonate had positive PCR results. The sequence analysis suggested 2 possible transmission routes: vertical and horizontal transmission in a newborn nursery and/or a family outside the hospital. The incubation period of PeV-A3 infection was estimated to be 1-3 days (maximum, 7 days).
conclusionHorizontal transmission of PeV-A3 was confirmed in a newborn nursery. Vertical transmission was suggested by the detection of RNA in an umbilical cord sample from the index case. These observations indicate that PeV-A3 can be horizontally transmitted in a newborn nursery and that special caution is required to prevent healthcare-associated transmission of PeV-A3.
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