Evidence map›Paper›PMID 37447866›Full record

ArticleSensors (Basel, Switzerland)2023

Automatic Assessment of the 2-Minute Walk Distance for Remote Monitoring of People with Multiple Sclerosis.

Spyridon Kontaxis, Estela Laporta, Esther Garcia, Matteo Martinis, Letizia Leocani, Lucia Roselli, Mathias Due Buron, Ana Isabel Guerrero, Ana Zabala, Nicholas Cummins and 12 more

Open access · goldAbstract read
In one paragraph

Article in Sensors (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Sensors in Multiple Sclerosis.Current neurology and neuroscience reports · 2025
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 6 institutions in 5 countries.

Spyridon KontaxisLaboratory of Biomedical Signal Interpretation and Computational Simulation (BSICoS), University of Zaragoza, 50018 Zaragoza, Spain.ORCID 0000-0002-1297-0691
Estela LaportaLaboratory of Biomedical Signal Interpretation and Computational Simulation (BSICoS), University of Zaragoza, 50018 Zaragoza, Spain.ORCID 0000-0001-6776-8522
Esther GarciaBiomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 28006 Barcelona, Spain.
Matteo MartinisDepartment of Medicine and Surgery, University Vita-Salute and Hospital San Raffaele, 20132 Milan, Italy.
Letizia LeocaniDepartment of Medicine and Surgery, University Vita-Salute and Hospital San Raffaele, 20132 Milan, Italy.
Lucia RoselliDepartment of Medicine and Surgery, University Vita-Salute and Hospital San Raffaele, 20132 Milan, Italy.
Mathias Due BuronDanish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital Rigshospitalet, 2100 Copenhagen, Denmark.ORCID 0000-0003-1260-1156
Ana Isabel GuerreroMultiple Sclerosis Center of Catalonia (CEMCAT), Department of Neurology/Neuroimmunology, Hospital Universitari Vall d'Hebron, Universitat Autonoma de Barcelona, 08035 Barcelona, Spain.ORCID 0000-0001-5891-2123
Ana ZabalaMultiple Sclerosis Center of Catalonia (CEMCAT), Department of Neurology/Neuroimmunology, Hospital Universitari Vall d'Hebron, Universitat Autonoma de Barcelona, 08035 Barcelona, Spain.ORCID 0000-0003-3860-5251
Nicholas CumminsDepartment of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, UK.
Srinivasan VairavanJanssen Research and Development, LLC, Titusville, NJ 08560, USA.
Matthew HotopfInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, UK.
Richard J B DobsonDepartment of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, UK.
Vaibhav A NarayanDavos Alzheimer's Collaborative, Wayne, PA 19087, USA.
Maria Libera La PortaDepartment of Medicine and Surgery, University Vita-Salute and Hospital San Raffaele, 20132 Milan, Italy.
Gloria Dalla CostaDepartment of Medicine and Surgery, University Vita-Salute and Hospital San Raffaele, 20132 Milan, Italy.
Melinda MagyariDanish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital Rigshospitalet, 2100 Copenhagen, Denmark.ORCID 0000-0002-0972-5222
Per Soelberg SørensenDanish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital Rigshospitalet, 2100 Copenhagen, Denmark.
Carlos NosMultiple Sclerosis Center of Catalonia (CEMCAT), Department of Neurology/Neuroimmunology, Hospital Universitari Vall d'Hebron, Universitat Autonoma de Barcelona, 08035 Barcelona, Spain.
Raquel BailonLaboratory of Biomedical Signal Interpretation and Computational Simulation (BSICoS), University of Zaragoza, 50018 Zaragoza, Spain.ORCID 0000-0003-1272-0550
Giancarlo ComiDepartment of Medicine and Surgery, University Vita-Salute and Hospital San Raffaele, 20132 Milan, Italy.
On Behalf Of The Radar-Cns Consortium
Vita-Salute San Raffaele University · ITUniversitat Autònoma de Barcelona · ESCopenhagen University Hospital · DKKing's College London · GBUniversidad de Zaragoza · ESJanssen (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to investigate the feasibility of automatically assessing the 2-Minute Walk Distance (2MWD) for monitoring people with multiple sclerosis (pwMS). For 154 pwMS, MS-related clinical outcomes as well as the 2MWDs as evaluated by clinicians and derived from accelerometer data were collected from a total of 323 periodic clinical visits. Accelerometer data from a wearable device during 100 home-based 2MWD assessments were also acquired. The error in estimating the 2MWD was validated for walk tests performed at hospital, and then the correlation (r) between clinical outcomes and home-based 2MWD assessments was evaluated. Robust performance in estimating the 2MWD from the wearable device was obtained, yielding an error of less than 10% in about two-thirds of clinical visits. Correlation analysis showed that there is a strong association between the actual and the estimated 2MWD obtained either at hospital (r = 0.71) or at home (r = 0.58). Furthermore, the estimated 2MWD exhibits moderate-to-strong correlation with various MS-related clinical outcomes, including disability and fatigue severity scores. Automatic assessment of the 2MWD in pwMS is feasible with the usage of a consumer-friendly wearable device in clinical and non-clinical settings. Wearable devices can also enhance the assessment of MS-related clinical outcomes.

Indexed as

Multiple SclerosisFatigueHumansWalkingWalk Testaccelerometer sensordisability levelfatigue severitywalk testswearable device

Identifiers

PMID37447866
PMCPMC10346544
OpenAlexW4382699489

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.