Evidence map›Paper›PMID 37447728›Full record

ArticleSensors (Basel, Switzerland)2023

Design and Evaluation of a Potential Non-Invasive Neurostimulation Strategy for Treating Persistent Anosmia in Post-COVID-19 Patients.

Desirée I Gracia, Mario Ortiz, Tatiana Candela, Eduardo Iáñez, Rosa M Sánchez, Carmina Díaz, José M Azorín

Open access · goldAbstract read
In one paragraph

Article in Sensors (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Trial
  2. Review
  3. Treatments for Olfactory Dysfunction in COVID-19: A Systematic Review.International archives of otorhinolaryngology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Desirée I GraciaBrain-Machine Interface Systems Lab, Miguel Hernandez University of Elche, 03202 Elche, Spain.ORCID 0000-0002-8855-1151
Mario OrtizBrain-Machine Interface Systems Lab, Miguel Hernandez University of Elche, 03202 Elche, Spain.ORCID 0000-0002-4269-1554
Tatiana CandelaBrain-Machine Interface Systems Lab, Miguel Hernandez University of Elche, 03202 Elche, Spain.
Eduardo IáñezBrain-Machine Interface Systems Lab, Miguel Hernandez University of Elche, 03202 Elche, Spain.ORCID 0000-0001-8057-5952
Rosa M SánchezDepartment of Neurology, Hospital General Universitario Dr. Balmis de Alicante, 03010 Alicante, Spain.
Carmina DíazDepartment of Neurology, Hospital General Universitario Dr. Balmis de Alicante, 03010 Alicante, Spain.ORCID 0000-0002-4495-5736
José M AzorínBrain-Machine Interface Systems Lab, Miguel Hernandez University of Elche, 03202 Elche, Spain.ORCID 0000-0001-5548-9657
Universitat de Miguel Hernández d'Elx · ESHospital General Universitario de Alicante Doctor Balmis · ES

Funding

Generalitat Valenciana GVA COVID19/2021/062
6 · The paper itself

Abstract

A new pandemic was declared at the end of 2019 because of coronavirus disease 2019 (COVID-19). One of the effects of COVID-19 infection is anosmia (i.e., a loss of smell). Unfortunately, this olfactory dysfunction is persistent in around 5% of the world's population, and there is not an effective treatment for it yet. The aim of this paper is to describe a potential non-invasive neurostimulation strategy for treating persistent anosmia in post-COVID-19 patients. In order to design the neurostimulation strategy, 25 subjects who experienced anosmia due to COVID-19 infection underwent an olfactory assessment while their electroencephalographic (EEG) signals were recorded. These signals were used to investigate the activation of brain regions during the olfactory process and identify which regions would be suitable for neurostimulation. Afterwards, 15 subjects participated in the evaluation of the neurostimulation strategy, which was based on applying transcranial direct current stimulation (tDCS) in selected brain regions related to olfactory function. The results showed that subjects with lower scores in the olfactory assessment obtained greater improvement than the other subjects. Thus, tDCS could be a promising option for people who have not fully regained their sense of smell following COVID-19 infection.

Indexed as

COVID-19Olfaction DisordersTranscranial Direct Current StimulationAnosmiaHumansSARS-CoV-2SmellanosmiaCOVID-19electroencephalographyneurostimulation

Identifiers

PMID37447728
PMCPMC10346661
OpenAlexW4382135838

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.