ArticleNutrients2023
Early-Life Nutrition in Preterm Infants and Risk of Respiratory Infections and Wheezing: A Scoping Review.
Article in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Beyond bronchopulmonary dysplasia: impact of human milk feeding on long-term respiratory morbidity in very preterm infants.European journal of pediatrics · 2026Article
- A study on differences in lung function development and longitudinal patterns between preterm infants of different gestational ages and term infants.Frontiers in pediatrics · 2026Article
- Development and validation of a perinatal risk prediction model for recurrent respiratory tract infections in moderate-to-late preterm infants: a retrospective cohort study.BMC pediatrics · 2025Article
- Early Enteral Feeding Restores Neurofilament Light Chain Serum Levels in Preterm Newborns.Current neuropharmacology · 2025Article
- Infant respiratory infections modulate lymphocyte homing to breast milk.Frontiers in immunology · 2024Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPreterm birth is a common early-life event that can lead to long-term consequences. The incidence of wheezing, asthma, and respiratory tract infections is higher in children born prematurely than in the general population. The purpose of this review was to synthesize the existing literature on the role of early-life nutrition in the later risk of respiratory morbidities.
methodsA scoping review of the literature was performed by searching three online databases. Inclusion criteria were: infants born <37 GWk, comparing human milk versus any other type of milk feeding formulation. Our primary outcomes were wheezing or asthma or respiratory tract infections after discharge. Two authors independently screened the results and extracted study characteristics using a predefined charting form.
resultsNine articles were included (eight cohort studies and one randomized trial). Four studies supported the protective effect of breastfeeding on wheezing or respiratory infections or both. Four studies did not confirm this association. One study confirmed the protective role of breastfeeding only on the subgroup of girls. There was a high heterogeneity among the included studies, in the type of milk feeding, outcomes, and age at follow-up.
conclusionsThe current evidence is conflicting. The high heterogeneity and methodological flaws could have influenced the results of the studies. Carefully designed studies are required to define the role of early-life nutrition among preterm infants on their long-term respiratory outcomes.
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