ArticleNutrients2023
Genetic Association and Potential Mediators between Sarcopenia and Coronary Heart Disease: A Bidirectional Two-Sample, Two-Step Mendelian Randomization Study.
Article in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 29 citations in OpenAlex.
- The association between sarcopenia, sedentary behavior, and the motor cognitive risk syndrome: A Mendelian randomization study.Medicine · 2026Article
- Viral infections and risk of mental illness: A Mendelian randomization study.Brain, behavior, & immunity - health · 2025Article
- Causal relationship and mediating role between depression and cognitive performance.The journal of prevention of Alzheimer's disease · 2025Article
- Detecting a potential causal relationship between plasma metabolites and myocardial infarction using bidirectional and two-step Mendelian randomization.Scientific reports · 2025Article
- Exploring potential therapeutic targets for cardiomyopathy: A proteome-wide Mendelian randomization analysis.Medicine · 2025Article
- Expression level and clinical significance of IL-29 in serum of patients with coronary heart disease.Journal of cardiothoracic surgery · 2025Article
- Causality of visceral adipose tissue on chronic kidney disease and renal function measure indicators, and mediation role of hypertension: Mendelian randomization study.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Review
- Association between sarcopenia and weight-adjusted waist index in male patients with type 2 diabetes.BMC endocrine disorders · 2025Article
- Occurrence of sarcopenia in elderly patients with coronary heart disease and its association with short-term prognosis.BMC cardiovascular disorders · 2025Article
- Impact of sarcopenia on ventricular remodelling following coronary artery bypass grafting in elderly patients with coronary heart disease.Frontiers in cardiovascular medicine · 2025Article
- The correlation between primary ovarian insufficiency, sex hormones and immune cells: a two-step Mendelian randomization study.Frontiers in endocrinology · 2025Article
- Exploring Causal Relationships Between Gut Microbiota, Inflammatory Cytokines, and Inflammatory Dermatoses: A Mendelian Randomization Study.Clinical, cosmetic and investigational dermatology · 2025Article
- The Role of Inflammatory Cytokines in the Causal Pathway From Gut Microbiota to Sjögren's Syndrome: Evidence From Mendelian Randomization.Mediators of inflammation · 2025Article
- The role of cerebrospinal fluid metabolites in mediating the impact of lipids on Late-Onset Alzheimer's Disease: a two-step mendelian randomization analysis.Journal of translational medicine · 2024Article
- Effects of immune cells in mediating the relationship between gut microbiota and myelodysplastic syndrome: a bidirectional two-sample, two-step Mendelian randomization study.Discover oncology · 2024Article
- Dissecting causal links between gut microbiota, inflammatory cytokines, and DLBCL: a Mendelian randomization study.Blood advances · 2024Article
- Causal relationship between nutritional assessment phenotypes and heart failure: A Mendelian randomization study.Heliyon · 2024Article
- Current approach to the diagnosis of sarcopenia in cardiovascular diseases.Frontiers in nutrition · 2024Review
- Hand grip strength and all-cause mortality risk in individuals with decreased bone mass: a study from NHANES database.Frontiers in medicine · 2024Article
- Causality between urate levels with sarcopenia-related traits: a bi-directional Mendelian randomization study.Frontiers in endocrinology · 2023Article
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Authors and funding
5 authors at 1 institution in 1 country.
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Abstract
objectiveTo elucidate the bidirectional correlation of sarcopenia with coronary heart disease (CHD), as well as to investigate the mediating role of cardiometabolic factors and inflammatory biomarkers, a bidirectional two-sample, two-step Mendelian randomization (MR) study was conducted.
methodsSummary statistics were obtained from genome-wide association studies (GWAS). In our bidirectional two-sample MR, genetic variants associated with sarcopenia-related traits and CHD were instrumented for the estimation of bidirectional correlations. Besides, genetic variants associated with thirteen cardiometabolic factors and six inflammatory biomarkers were selected for further mediation analyses. To confirm the consistency of the results, several sensitivity analyses were carried out.
resultsGenetically predicted higher appendicular lean mass (OR = 0.835, 95% CI: 0.790-0.882), left hand grip strength (OR = 0.703, 95% CI: 0.569-0.869), right hand grip strength (OR = 0.685, 95% CI: 0.555-0.844), and walking pace (OR = 0.321, 95% CI: 0.191-0.539) reduced CHD risk, while genetic predisposition to CHD did not affect any of the sarcopenia-related traits. Seven mediators were identified for the effects of appendicular lean mass on CHD, including waist-to-hip ratio, hip circumference, systolic blood pressure, low-density lipoprotein cholesterol, total cholesterol, triglycerides, and fasting insulin. The mediation proportion ranged from 10.23% for triglycerides to 35.08% for hip circumference. Hip circumference was found to mediate the relationships between both left (mediation proportion: 24.61%) and right-hand grip strength (24.14%) and CHD, and the link between walking pace and CHD was partially mediated by waist-to-hip ratio (31.15%) and body mass index (26.66%).
conclusionOur results showed that higher appendicular lean mass, hand grip strength, and walking pace reduced CHD risk, but the causal relationship was not bidirectional. Several mediators were found to mediate the causal pathways between sarcopenia-related traits and CHD, and intervention of these factors may be helpful in terms of CHD prevention in sarcopenia patients.
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