Evidence map›Paper›PMID 37447243›Full record

ArticleNutrients2023

Early Energy Intake and Amino Acid Profile in Preterm Newborns: A Quasi-Experimental Study.

Giovanni Boscarino, Claudia Carducci, Maria Giulia Conti, Maria Podagrosi, Annamaria Gigliello, Maria Di Chiara, Monica Bartolucci, Roberto Brunelli, Pasquale Parisi, Antonio Angeloni and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Giovanni BoscarinoDepartment of Maternal and Child Health, Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0003-2481-0692
Claudia CarducciDepartment of Experimental Medicine, Policlinico Umberto I, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0003-0515-9208
Maria Giulia ContiDepartment of Maternal and Child Health, Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, Italy.
Maria PodagrosiDepartment of Maternal and Child Health, Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, Italy.
Annamaria GiglielloDepartment of Experimental Medicine, Policlinico Umberto I, Sapienza University of Rome, 00185 Rome, Italy.
Maria Di ChiaraDepartment of Maternal and Child Health, Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0001-6916-7800
Monica BartolucciDepartment of Maternal and Child Health, Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, Italy.
Roberto BrunelliDepartment of Maternal and Child Health, Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, Italy.
Pasquale ParisiDepartment of Neuroscience, Mental Health and Sense Organs (NESMOS), Faculty of Medicine and Psychology, Sant Andrea Hospital University, Sapienza University of Rome, 00189 Rome, Italy.ORCID 0000-0001-9042-8120
Antonio AngeloniDepartment of Experimental Medicine, Policlinico Umberto I, Sapienza University of Rome, 00185 Rome, Italy.
Gianluca TerrinDepartment of Maternal and Child Health, Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0003-3541-2876
Policlinico Umberto I · ITSapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(1) Background: An increased protein intake via parenteral nutrition (PN) in early life is associated with an improvement of the nitrogen balance in preterm newborns. However, the role of energy intake on amino acid (AA) utilization provided by PN remains to be defined. We investigated the effects of energy intake on blood AA levels and profiles. (2) Methods: Quasi-experimental study including preterm very low birth weight newborns who received an energy enhanced PN (Cohort A) or an energy standard PN (Cohort B), with a similar protein amount in the first week of life. Blood AA levels were measured between three and seven days of life (T0) and at fifteen days of life (T1) and compared between the two study cohorts. (3) Results: AA levels of 40 newborns from each group were analyzed. No difference was found for total essential and non-essential blood AA concentration at T0 between the two study cohorts. At T1, we found a significantly higher blood concentration of leucine, isoleucine and proline, and a significantly lower concentration of tyrosine in Cohort B. However, multivariate analysis did not confirm this result. (4) Conclusions: An enhanced PN protocol in terms of energy but not of protein did not influence AA levels and profiles. Considering the high risk of side effects, we suggest exercising caution when administering high energy intake via PN in the first week of life.

Indexed as

Amino AcidsInfant, PrematureEnergy IntakeHumansInfant, NewbornLeucineParenteral NutritionAmino AcidsLeucineisoleucineleucineneonatenutritionnutritional intakeparenteral nutritionplasma amino acidprolineprotein intaketyrosinevery low birth weight

Identifiers

PMID37447243
PMCPMC10343583
OpenAlexW4382403293

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.