Evidence map›Paper›PMID 37447210›Full record

Trial reportNutrients2023

Combination of Chemically Characterized Pomegranate Extract and Hydrophilic Vitamins against Prolonged Fatigue: A Monocentric, Randomized, Double-Blind, Placebo-Controlled Clinical Trial.

Hammad Ullah, Eduardo Sommella, Alessandro Di Minno, Roberto Piccinocchi, Daniele Giuseppe Buccato, Lorenza Francesca De Lellis, Costanza Riccioni, Alessandra Baldi, Hesham R El-Seedi, Shaden A M Khalifa and 4 more

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 4 countries.

Hammad UllahDepartment of Pharmacy, University of Napoli Federico II, Via D. Montesano 49, 80131 Naples, Italy.ORCID 0000-0001-9437-676X
Eduardo SommellaDepartment of Pharmacy, University of Salerno, 84084 Fisciano, Italy.
Alessandro Di MinnoDepartment of Pharmacy, University of Napoli Federico II, Via D. Montesano 49, 80131 Naples, Italy.ORCID 0000-0001-8084-9976
Roberto PiccinocchiLevel 1 Medical Director Anaesthesia and Resuscitation A. U. O. Luigi Vanvitelli, Via Santa Maria di Costantinopoli, 80138 Naples, Italy.
Daniele Giuseppe BuccatoDepartment of Pharmacy, University of Napoli Federico II, Via D. Montesano 49, 80131 Naples, Italy.
Lorenza Francesca De LellisDepartment of Pharmacy, University of Napoli Federico II, Via D. Montesano 49, 80131 Naples, Italy.
Costanza RiccioniR&D Department, Esserre Pharma Srl, 00191 Rome, Italy.ORCID 0000-0003-1527-8024
Alessandra BaldiDepartment of Pharmacy, University of Napoli Federico II, Via D. Montesano 49, 80131 Naples, Italy.ORCID 0000-0002-2877-9445
Hesham R El-SeediInternational Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang 212013, China.
Shaden A M KhalifaPsychiatry and Psychology Department, Capio Saint Göran's Hospital, Sankt Göransplan 1, 112 19 Stockholm, Sweden.
Gaetano PiccinocchiComegen S.c.S., Società Cooperativa Sociale di Medici di Medicina Generale, Viale Maria Bakunin 41, 80125 Naples, Italy.
Pietro CampigliaDepartment of Pharmacy, University of Salerno, 84084 Fisciano, Italy.ORCID 0000-0002-1069-2181
Roberto SacchiApplied Statistic Unit, Department of Earth and Environmental Sciences, University of Pavia, Viale Taramelli 24, 27100 Pavia, Italy.ORCID 0000-0002-6199-0074
Maria DagliaDepartment of Pharmacy, University of Napoli Federico II, Via D. Montesano 49, 80131 Naples, Italy.ORCID 0000-0002-4870-7713
University of Naples Federico II · ITJiangsu University · CNUniversity of Salerno · ITCeinge Biotecnologie Avanzate (Italy) · ITSaint Göran Hospital · SESocietà Italiana di Medicina Generale · ITUniversity of Pavia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prolonged fatigue is associated with non-pathological causes and lacks an established therapeutic approach. The current study is aimed at assessing the efficacy of a new food supplement (Improve™) based on a chemically characterized pomegranate extract and hydro-soluble vitamins (B complex and C). UHPLC-HRMS analysis of pomegranate extract showed the presence of 59 compounds, with gallotannins and ellagitannins being the most abundant phytochemicals. For the clinical study, 58 subjects were randomized into two groups, 1 and 2 (

Indexed as

PomegranateVitaminsDietary SupplementsDouble-Blind MethodFatigueHumansVitamin AVitamin KVitamin AVitamin KVitaminspolyphenolspomegranate extractprolonged fatiguevitamin B complexvitamin C

Identifiers

PMID37447210
PMCPMC10343643
OpenAlexW4382450056

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.