ArticleNutrients2023
Sex Specificity in the Mixed Effects of Blood Heavy Metals and Cognitive Function on Elderly: Evidence from NHANES.
Article in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 45 citations in OpenAlex.
- Study on the correlation between serum lead levels and allergic rhinitis in adults and IgE levels.Medicine · 2026Article
- Associations of blood heavy metals with cognitive function in older US adults: single and mutually adjusted effects.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Observational
- Association of Multiple Plasma Metals With Cerebral Microbleeds: A Brain Magnetic Resonance Imaging-Based Study.Journal of the American Heart Association · 2026Article
- Serum Creatinine Clearance and Cognitive Function in Older Adults: Mediating Effects of Systemic Inflammatory Response Index.Brain and behavior · 2026Article
- The mediating role of vascular age in the association between blood metals and atherosclerosis from Manganese-exposed workers healthy cohort.BMC public health · 2026Article
- Investigating the causal impact of gut microbiota on periodontitis based on Mendelian randomization, bulk transcriptomics, and single-cell transcriptomics.Frontiers in cell and developmental biology · 2026Article
- Impact of greenhouse gases and air pollutants on the incidence and mortality of HBV and HCV in China.Frontiers in public health · 2026Article
- Heavy metal mixtures exposure and breast cancer risk: synergistic effects with SHBG identified by mediation and moderation models.BMC public health · 2025Article
- Metals and metalloids concentrations in adults aged 50 and older from Mexico.Research square · 2025Article
- Association among persistent chemical pollutants and infectious encephalitis: a mixture exposure and mediation approach.BMC public health · 2025Article
- Protective Role of Multiple Essential Minerals Against Cadmium-Related Cognitive Decline in Middle-Aged and Older Adults: A Prospective Study.Nutrients · 2025Article
- Associations between multiple metals exposure and bone mineral density: a population-based study in U.S. children and adolescents.BMC musculoskeletal disorders · 2025Article
- Article
- Associations between heavy metal exposure and vascular age: a large cross-sectional study.Journal of translational medicine · 2025Article
- Inflammation mediation of the association between brominated flame retardants and psoriasis among U.S. adults.Frontiers in public health · 2025Article
- Exposure to Cadmium and Other Trace Elements Among Individuals with Mild Cognitive Impairment.Toxics · 2024Article
- Association between blood heavy metals and fecal incontinence in American adults: A population-based study.BMC public health · 2024Article
- Organic food consumption is positively associated with cognitive function among middle-aged and older adults: cross-sectional and longitudinal analyses.European journal of nutrition · 2024Article
- The Effect of Nutrients on Neurological Disorders.Nutrients · 2024Article
- Single and joint exposure of Pb, Cd, Hg, Se, Cu, and Zn were associated with cognitive function of older adults.Scientific reports · 2024Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
The way that males and females react to environmental exposures and negative impacts on their neurological systems is often different. Although previous research has examined the cognitively impairing effects of solitary metal exposures, the relationship between metal mixtures and cognitive function, particularly when considering an individual's sex, remains elusive. This study aimed to investigate the sex differences in the association between multiple metal combinations and cognitive function in older Americans. This research employed the 2011-2014 NHANES survey of elderly Americans. The association between five mixed metals and four cognitive tests (the animal fluency test (AFT), the digit symbol substitution test (DSST), the instant recall test (IRT), and the delayed recall test (DRT)) were investigated with generalized linear regression model (GLM), Bayesian kernel machine regression model (BKMR), weighted quantile sum regression model (WQS), and quantile g-computation regression model (Qgcomp). A total of 1833 people, including 883 males and 950 females, enrolled in this cross-sectional study. We discovered that blood lead and blood cadmium were negatively associated with cognitive performance, while blood selenium demonstrated a positive association with cognitive function in older people. The negative relationship of heavy metal combinations on cognitive function might be somewhat reduced or even reversed via selenium. The IRT, AFT, and DSST are three of the four cognitive tests where men had more dramatic positive or negative results. There was a sex-specific connection between blood metal ratios and cognitive function among older Americans, as evidenced by the more significant relationship between mixed metals and cognitive performance in men (either positively or negatively). These results emphasize the impacts of ambient heavy metal exposure on cognitive function by employing sex-specific methods.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.