Evidence map›Paper›PMID 37447162›Full record

ArticleNutrients2023

Stingless Bee (

Mohamad Zulhafiz Shafiq Zulhilmi Cheng, Fatin Aina Zulkhairi Amin, Norhasnida Zawawi, Kim Wei Chan, Norsharina Ismail, Nur Akmal Ishak, Norhaizan Mohd Esa

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Kelulut honey (Toxicology reports · 2026
    Review
  2. Review
  3. Article
  4. Malícia honey (Frontiers in nutrition · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Mohamad Zulhafiz Shafiq Zulhilmi ChengNatural Medicines and Products Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia.ORCID 0000-0003-0432-2552
Fatin Aina Zulkhairi AminNatural Medicines and Products Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia.
Norhasnida ZawawiDepartment of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia.ORCID 0000-0001-7459-5025
Kim Wei ChanNatural Medicines and Products Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia.ORCID 0000-0003-3028-0800
Norsharina IsmailNatural Medicines and Products Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia.ORCID 0000-0002-2580-8300
Nur Akmal IshakNatural Medicines and Products Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia.
Norhaizan Mohd EsaNatural Medicines and Products Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia.ORCID 0000-0003-1545-0306
Universiti Putra Malaysia · MY

Funding

Ministry of Education TRGS/1/2016/UPM/01/5/4
6 · The paper itself

Abstract

Diabetes is associated with an imbalance between oxidants and antioxidants, leading to oxidative stress. This imbalance contributes to the development and progression of diabetic complications. Similarly, renal and liver diseases are characterised by oxidative stress, where an excess of oxidants overwhelms the antioxidant defense mechanisms, causing tissue damage and dysfunction. Restoring the oxidant-antioxidant balance is essential for mitigating oxidative stress-related damage under these conditions. In this current study, the efficacy of stingless bee honey (SBH) and its phenolic-rich extract (PRE) in controlling the oxidant-antioxidant balance in high-fat diet- and streptozotocin/nicotinamide-induced diabetic rats was investigated. The administration of SBH and PRE improved systemic antioxidant defense and oxidative stress-related measures without compromising liver and renal functioning. Analyses of the liver, skeletal muscle and adipose tissues revealed differences in their capacities to scavenge free radicals and halt lipid peroxidation. Transcriptional alterations hypothesised tissue-specific control of KEAP1-NRF2 signalling by upregulation of

Indexed as

Diabetes Mellitus, ExperimentalHoneyAnimalsAntioxidantsBeesKelch-Like ECH-Associated Protein 1NF-E2-Related Factor 2OxidantsOxidative StressPhenolsRatsAntioxidantsKEAP1 protein, ratKelch-Like ECH-Associated Protein 1NF-E2-Related Factor 2OxidantsPhenolsKEAP1-NRF2 signallingoxidative stressphenolic-rich extractstingless bee honey

Identifiers

PMID37447162
PMCPMC10343317
OpenAlexW4381805120

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.