Evidence map›Paper›PMID 37446864›Full record

ReviewMolecules (Basel, Switzerland)2023

Heterocyclic Iminoquinones and Quinones from the National Cancer Institute (NCI, USA) COMPARE Analysis.

Naemah Haji, Masoma Faizi, Panayiotis A Koutentis, Michael P Carty, Fawaz Aldabbagh

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Naemah HajiDepartment of Pharmacy, School of Life Sciences, Pharmacy and Chemistry, Kingston University, Penrhyn Road, Kingston upon Thames, London KT1 2EE, UK.
Masoma FaiziDepartment of Pharmacy, School of Life Sciences, Pharmacy and Chemistry, Kingston University, Penrhyn Road, Kingston upon Thames, London KT1 2EE, UK.
Panayiotis A KoutentisDepartment of Chemistry, University of Cyprus, P.O. Box 20537, Nicosia 1678, Cyprus.ORCID 0000-0002-4652-7567
Michael P CartySchool of Biological and Chemical Sciences, University of Galway, University Road, H91 TK33 Galway, Ireland.ORCID 0000-0002-0342-9297
Fawaz AldabbaghDepartment of Pharmacy, School of Life Sciences, Pharmacy and Chemistry, Kingston University, Penrhyn Road, Kingston upon Thames, London KT1 2EE, UK.ORCID 0000-0001-8356-5258
Kingston University · GBOllscoil na Gaillimhe – University of Galway · IEUniversity of Cyprus · CY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This review uses the National Cancer Institute (NCI) COMPARE program to establish an extensive list of heterocyclic iminoquinones and quinones with similarities in differential growth inhibition patterns across the 60-cell line panel of the NCI Developmental Therapeutics Program (DTP). Many natural products and synthetic analogues are revealed as potential NAD(P)H:quinone oxidoreductase 1 (NQO1) substrates, through correlations to dipyridoimidazo[5,4-

Indexed as

Antineoplastic AgentsIndolequinonesNeoplasmsBenzoquinonesNAD(P)H Dehydrogenase (Quinone)National Cancer Institute (U.S.)OxidoreductasesQuinonesUnited StatesAntineoplastic AgentsBenzoquinonesiminoquinoneIndolequinonesNAD(P)H Dehydrogenase (Quinone)OxidoreductasesquinoneQuinonesbioreductionheterocyclesnatural productsNQO1reductasessynthesisthioredoxin

Identifiers

PMID37446864
PMCPMC10343902
OpenAlexW4383227299

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.