Evidence map›Paper›PMID 37446842›Full record

ArticleMolecules (Basel, Switzerland)2023

Bayesian Optimization-Assisted Screening to Identify Improved Reaction Conditions for Spiro-Dithiolane Synthesis.

Masaru Kondo, Hettiarachchige Dona Piyumi Wathsala, Kazunori Ishikawa, Daisuke Yamashita, Takeshi Miyazaki, Yoji Ohno, Hiroaki Sasai, Takashi Washio, Shinobu Takizawa

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 9 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Masaru KondoSANKEN, Osaka University, Ibaraki-shi 567-0047, Japan.
Hettiarachchige Dona Piyumi WathsalaAsahi Chemical Co., Ltd., Mitsuya-Minami, Yodogawa Ward, Osaka-shi 532-0035, Japan.
Kazunori IshikawaSANKEN, Osaka University, Ibaraki-shi 567-0047, Japan.
Daisuke YamashitaAsahi Chemical Co., Ltd., Mitsuya-Minami, Yodogawa Ward, Osaka-shi 532-0035, Japan.
Takeshi MiyazakiAsahi Chemical Co., Ltd., Mitsuya-Minami, Yodogawa Ward, Osaka-shi 532-0035, Japan.
Yoji OhnoAsahi Chemical Co., Ltd., Mitsuya-Minami, Yodogawa Ward, Osaka-shi 532-0035, Japan.
Hiroaki SasaiSANKEN, Osaka University, Ibaraki-shi 567-0047, Japan.ORCID 0000-0002-7221-488X
Takashi WashioSANKEN, Osaka University, Ibaraki-shi 567-0047, Japan.
Shinobu TakizawaSANKEN, Osaka University, Ibaraki-shi 567-0047, Japan.ORCID 0000-0002-9668-1888
Asahi Chemical & Industry (Japan) · JPThe University of Osaka · JPIbaraki University · JP

Funding

Japan Science and Technology Agency JPMJCR1666Japan Science and Technology Agency JPMJCR20R1Japan Society for the Promotion of Science 21A204Japan Society for the Promotion of Science 21H05207Japan Society for the Promotion of Science 21H05217Japan Society for the Promotion of Science 22K06502
6 · The paper itself

Abstract

Bayesian optimization (BO)-assisted screening was applied to identify improved reaction conditions toward a hundred-gram scale-up synthesis of 2,3,7,8-tetrathiaspiro[4.4]nonane (

Indexed as

Bayesian optimization (BO)Gaussian process regression (GPR)Latin hypercube sampling (LHS)process chemistryrandom screeningscalable synthesisspiro-dithiolane

Identifiers

PMID37446842
PMCPMC10343712
OpenAlexW4382936540

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.