Evidence map›Paper›PMID 37446813›Full record

ArticleMolecules (Basel, Switzerland)2023

Insights into the Antioxidant/Antiradical Effects and In Vitro Intestinal Permeation of Oleocanthal and Its Metabolites Tyrosol and Oleocanthalic Acid.

Doretta Cuffaro, Diana Pinto, Ana Margarida Silva, Andrea Bertolini, Simone Bertini, Alessandro Saba, Marco Macchia, Francisca Rodrigues, Maria Digiacomo

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Doretta CuffaroDepartment of Pharmacy, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0002-8842-542X
Diana PintoREQUIMTE/LAQV, ISEP, Polytechnic Institute of Porto, Rua Dr. António Bernardino de Almeida, 4249-015 Porto, Portugal.ORCID 0000-0001-8534-3739
Ana Margarida SilvaREQUIMTE/LAQV, ISEP, Polytechnic Institute of Porto, Rua Dr. António Bernardino de Almeida, 4249-015 Porto, Portugal.ORCID 0000-0002-1823-9816
Andrea BertoliniDepartment of Surgery, Medical, Molecular and Critical Area Pathology, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0003-4810-7061
Simone BertiniDepartment of Pharmacy, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0001-8832-8075
Alessandro SabaDepartment of Surgery, Medical, Molecular and Critical Area Pathology, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0003-0611-5549
Marco MacchiaDepartment of Pharmacy, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0002-5565-2044
Francisca RodriguesREQUIMTE/LAQV, ISEP, Polytechnic Institute of Porto, Rua Dr. António Bernardino de Almeida, 4249-015 Porto, Portugal.ORCID 0000-0001-8803-0041
Maria DigiacomoDepartment of Pharmacy, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0003-0653-6642
University of Pisa · ITRede de Química e Tecnologia · PT

Funding

Ministry of University and Research PON 2014-2020 "Research and In-novation" resources - Green/Innovation Action - DM MUR 1062/2021national funds UIDB/50006/2020, UIDP/50006/2020University of Pisa PRA Progetti di Ricerca di Ateneo" (Institutional Research Grants)-Project No. PRA_2020-2021 "Agenti innovativi e nanosistemi per target molecolari nell'ambito dell'oncologia"
6 · The paper itself

Abstract

(1) Background: In recent years, numerous studies have highlighted the beneficial effects of extra virgin olive oil (EVOO) as an active ingredient against chronic diseases. The properties of EVOO are due to its peculiar composition, mainly to its rich content of polyphenols. In fact, polyphenols may contribute to counteract oxidative stress, which often accompanies chronic diseases. In this work, the antioxidant effects of high-value polyphenol oleocanthal (OC) and its main metabolites, tyrosol (Tyr) and oleocanthalic acid (OA), respectively, have been investigated along with their impact on cell viability. (2) Methods: OC, Tyr, and OA have been evaluated regarding antiradical properties in term of scavenging capacity towards biologically relevant reactive species, including O

Indexed as

AntioxidantsPolyphenolsAldehydesCaco-2 CellsCyclopentane MonoterpenesHumansOlive OilPhenolsPhenylethyl Alcohol4-hydroxyphenylethanolAldehydesAntioxidantsCyclopentane MonoterpenesoleocanthalOlive OilPhenolsPhenylethyl AlcoholPolyphenolsantioxidant activityintestinal permeationmetabolismoleocanthaloleocanthalic acidpolyphenolstyrosol

Identifiers

PMID37446813
PMCPMC10343523
OpenAlexW4382936489

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.