Investigation of the Relationship between Electronic Structures and Bioactivities of Polypyridyl Ru(II) Complexes.

Zhiying Hou, Yang Lu, Bin Zhang, A F M Motiur Rahman, Yufen Zhao, Ning Xi, Ning Wang, Jinhui Wang

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Computer-aided discovery of novel SmDHODH inhibitors for schistosomiasis therapy: Ligand-based drug design, molecular docking, molecular dynamic simulations, drug-likeness, and ADMET studies.PLoS neglected tropical diseases · 2024
Article

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhiying HouInstitute of Drug Discovery Technology (IDDT), Ningbo University, Ningbo 315211, China.

Yang LuInstitute of Drug Discovery Technology (IDDT), Ningbo University, Ningbo 315211, China.

Bin ZhangLi Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo 315800, China.ORCID 0000-0002-4371-4746

A F M Motiur RahmanDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.ORCID 0000-0002-5807-5625

Yufen ZhaoInstitute of Drug Discovery Technology (IDDT), Ningbo University, Ningbo 315211, China.

Ning XiInstitute of Drug Discovery Technology (IDDT), Ningbo University, Ningbo 315211, China.

Ning WangInstitute of Drug Discovery Technology (IDDT), Ningbo University, Ningbo 315211, China.ORCID 0000-0002-5625-5358

Jinhui WangInstitute of Drug Discovery Technology (IDDT), Ningbo University, Ningbo 315211, China.ORCID 0000-0001-7024-3313

Funding

National Natural Science Foundation of China Project 81901811Natural Science Foundation of Ningbo City 2021J104Ningbo Public Welfare Science and Technology Project 2019C50072Ningbo Top Talent Project 215-432094250Science and Technology Plan Project of Ningbo City 2022S128Scientific Research Grant of Ningbo University 215-432000282

6 · The paper itself

Abstract

Ruthenium (Ru)-based organometallic drugs have gained attention as chemotherapeutic and bioimaging agents due to their fewer side effects and excellent physical optical properties. Tuning the electronic structures of Ru complexes has been proven to increase the cytotoxicity of cancer cells and the luminescent efficiency of the analytical probes. However, the relationship between electronic structures and bioactivities is still unclear due to the potential enhancement of both electron donor and acceptor properties. Thus, we investigated the relationship between the electronic structures of Ru(II) complexes and cytotoxicity by optimizing the electron-withdrawing (complex

Indexed as

Coordination ComplexesRutheniumDensity Functional TheoryDNAPyridinesCoordination ComplexesDNAPyridinesRutheniumbioimagingcytotoxicityelectronic structureoff-onphenanthrolineruthenium complex

Identifiers

PMID37446696

DOI10.3390/molecules28135035

PMCPMC10343301

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.