Evidence map›Paper›PMID 37446650›Full record

ReviewMolecules (Basel, Switzerland)2023

Protein-Based Hydrogels and Their Biomedical Applications.

Kok Zhi Lee, Juya Jeon, Bojing Jiang, Shri Venkatesh Subramani, Jingyao Li, Fuzhong Zhang

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Article
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  6. Review
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  8. EnhancingApplied and environmental microbiology · 2025
    Article
  9. Review
  10. Biohybrid Computing with Proteinoids and Algae.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  11. Review
  12. Review
  13. Review
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  15. Article
  16. Review
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kok Zhi LeeDepartment of Energy, Environmental & Chemical Engineering, Washington University in St. Louis, One Brookings Drive, Saint Louis, MI 63130, USA.ORCID 0000-0002-1836-2662
Juya JeonDepartment of Energy, Environmental & Chemical Engineering, Washington University in St. Louis, One Brookings Drive, Saint Louis, MI 63130, USA.ORCID 0000-0001-7723-9413
Bojing JiangDepartment of Energy, Environmental & Chemical Engineering, Washington University in St. Louis, One Brookings Drive, Saint Louis, MI 63130, USA.ORCID 0000-0001-6674-0464
Shri Venkatesh SubramaniDepartment of Energy, Environmental & Chemical Engineering, Washington University in St. Louis, One Brookings Drive, Saint Louis, MI 63130, USA.
Jingyao LiDepartment of Energy, Environmental & Chemical Engineering, Washington University in St. Louis, One Brookings Drive, Saint Louis, MI 63130, USA.ORCID 0000-0002-6834-4681
Fuzhong ZhangDepartment of Energy, Environmental & Chemical Engineering, Washington University in St. Louis, One Brookings Drive, Saint Louis, MI 63130, USA.

Funding

National Science Foundation DMR-2105150, DMR-2207879, OIA-2219142United States Department of Agriculture 20196702129943
6 · The paper itself

Abstract

Hydrogels made from proteins are attractive materials for diverse medical applications, as they are biocompatible, biodegradable, and amenable to chemical and biological modifications. Recent advances in protein engineering, synthetic biology, and material science have enabled the fine-tuning of protein sequences, hydrogel structures, and hydrogel mechanical properties, allowing for a broad range of biomedical applications using protein hydrogels. This article reviews recent progresses on protein hydrogels with special focus on those made of microbially produced proteins. We discuss different hydrogel formation strategies and their associated hydrogel properties. We also review various biomedical applications, categorized by the origin of protein sequences. Lastly, current challenges and future opportunities in engineering protein-based hydrogels are discussed. We hope this review will inspire new ideas in material innovation, leading to advanced protein hydrogels with desirable properties for a wide range of biomedical applications.

Indexed as

Biocompatible MaterialsHydrogelsProteinsTissue EngineeringBiocompatible MaterialsHydrogelsProteinshydrogelsmicrobial expressionprotein hydrogelprotein polymersrecombinant proteinssynthetic biology

Identifiers

PMID37446650
PMCPMC10343515

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.