Evidence map›Paper›PMID 37446578›Full record

ArticleMolecules (Basel, Switzerland)2023

Lipophilic Fe(III)-Complex with Potent Broad-Spectrum Anticancer Activity and Ability to Overcome Pt Resistance in A2780cis Cancer Cells.

Nalin Abeydeera, Morgan Stilgenbauer, Bishnu D Pant, Khalil Mudarmah, Thiloka M Dassanayake, Yao-Rong Zheng, Songping D Huang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Rapid and Efficient Solid-State Mechanosynthesis of Bipyridine Metal Complexes.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Nalin AbeydeeraDepartment of Chemistry and Biochemistry, Kent State University, Kent, OH 44240, USA.
Morgan StilgenbauerDepartment of Chemistry and Biochemistry, Kent State University, Kent, OH 44240, USA.ORCID 0000-0001-5575-3577
Bishnu D PantDepartment of Chemistry and Biochemistry, Kent State University, Kent, OH 44240, USA.
Khalil MudarmahDepartment of Chemistry and Biochemistry, Kent State University, Kent, OH 44240, USA.
Thiloka M DassanayakeDepartment of Chemistry and Biochemistry, Kent State University, Kent, OH 44240, USA.
Yao-Rong ZhengDepartment of Chemistry and Biochemistry, Kent State University, Kent, OH 44240, USA.
Songping D HuangDepartment of Chemistry and Biochemistry, Kent State University, Kent, OH 44240, USA.
Kent State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although iron is essential for all forms of life, it is also potentially toxic to cells as the increased and unregulated iron uptake can catalyze the Fenton reaction to produce reactive oxygen species (ROS), leading to lipid peroxidation of membranes, oxidation of proteins, cleavage of DNA and even activation of apoptotic cell death pathways. We demonstrate that Fe(hinok)

Indexed as

Antineoplastic AgentsOvarian NeoplasmsApoptosisCell Line, TumorFemaleFerric CompoundsHEK293 CellsHumansIronAntineoplastic AgentsFerric CompoundsIronFe(III) coordination compoundFenton catalystIronROS signaling pathways

Identifiers

PMID37446578
PMCPMC10343305
OpenAlexW4381805980

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.