Evidence map›Paper›PMID 37446397›Full record

ReviewInternational journal of molecular sciences2023

Investigating the Crime Scene-Molecular Signatures in Inflammatory Bowel Disease.

Vibeke Andersen, Tue B Bennike, Corinna Bang, John D Rioux, Isabelle Hébert-Milette, Toshiro Sato, Axel K Hansen, Ole H Nielsen

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 4 countries.

Vibeke AndersenMolecular Diagnostic and Clinical Research Unit, University Hospital of Southern Denmark, Institute of Regional Research, University of Southern Denmark, 5000 Odense, Denmark.ORCID 0000-0002-0127-2863
Tue B BennikeMolecular Diagnostic and Clinical Research Unit, University Hospital of Southern Denmark, Institute of Regional Research, University of Southern Denmark, 5000 Odense, Denmark.ORCID 0000-0003-4354-1731
Corinna BangInstitute for Clinical Molecular Biology, Christian-Albrecht's University, 24105 Kiel, Germany.
John D RiouxDepartment of Medicine, Université de Montréal, Montreal, QC H3C 3J7, Canada.
Isabelle Hébert-MiletteDepartment of Medicine, Université de Montréal, Montreal, QC H3C 3J7, Canada.
Toshiro SatoDepartment of Gastroenterology, Keio University School of Medicine, Tokyo 160-8582, Japan.
Axel K HansenExperimental Animal Models, Department of Veterinary and Animal Sciences, University of Copenhagen, 1870 Frederiksberg, Denmark.ORCID 0000-0003-1575-2507
Ole H NielsenDepartment of Gastroenterology, Herlev Hospital, University of Copenhagen, 2730 Herlev, Denmark.ORCID 0000-0003-4612-8635
Montreal Heart Institute · CAUniversity of Copenhagen · DKUniversity of Southern Denmark · DKChristian-Albrechts-Universität zu Kiel · DEKeio University · JP

Funding

Universite de Montreal IBD Genetics Research CenterU01DK062432 · NIDDK · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI John D. Rioux · 2002 to 2026
$9.6M
NIDDK NIH HHS U01 DK062432
6 · The paper itself

Abstract

Inflammatory bowel diseases (IBD) are without cure and troublesome to manage because of the considerable diversity between patients and the lack of reliable biomarkers. Several studies have demonstrated that diet, gut microbiota, genetics and other patient factors are essential for disease occurrence and progression. Understanding the link between these factors is crucial for identifying molecular signatures that identify biomarkers to advance the management of IBD. Recent technological breakthroughs and data integration have fuelled the intensity of this research. This research demonstrates that the effect of diet depends on patient factors and gut microbial activity. It also identifies a range of potential biomarkers for IBD management, including mucosa-derived cytokines, gasdermins and neutrophil extracellular traps, all of which need further evaluation before clinical translation. This review provides an update on cutting-edge research in IBD that aims to improve disease management and patient quality of life.

Indexed as

Colitis, UlcerativeGastrointestinal MicrobiomeInflammatory Bowel DiseasesBiomarkersDietHumansQuality of LifeBiomarkersbiomarkersCrohn’s diseasegut microbiotaintestinal barrierpersonalised medicineulcerative colitis

Identifiers

PMID37446397
PMCPMC10342864
OpenAlexW4383723548

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.