Evidence map›Paper›PMID 37446391›Full record

ArticleInternational journal of molecular sciences2023

Dopamine D3 Receptor Modulates Akt/mTOR and ERK

Aurelio Franco-García, Rocío Guerrero-Bautista, Juana María Hidalgo, Victoria Gómez-Murcia, María Victoria Milanés, Cristina Núñez

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Aurelio Franco-GarcíaGroup of Cellular and Molecular Pharmacology, Department of Pharmacology, CEIR Campus Mare Nostrum, University of Murcia, 30120 Murcia, Spain.ORCID 0000-0002-6141-2303
Rocío Guerrero-BautistaGroup of Cellular and Molecular Pharmacology, Department of Pharmacology, CEIR Campus Mare Nostrum, University of Murcia, 30120 Murcia, Spain.
Juana María HidalgoGroup of Cellular and Molecular Pharmacology, Department of Pharmacology, CEIR Campus Mare Nostrum, University of Murcia, 30120 Murcia, Spain.
Victoria Gómez-MurciaGroup of Cellular and Molecular Pharmacology, Department of Pharmacology, CEIR Campus Mare Nostrum, University of Murcia, 30120 Murcia, Spain.ORCID 0000-0003-4626-2674
María Victoria MilanésGroup of Cellular and Molecular Pharmacology, Department of Pharmacology, CEIR Campus Mare Nostrum, University of Murcia, 30120 Murcia, Spain.
Cristina NúñezGroup of Cellular and Molecular Pharmacology, Department of Pharmacology, CEIR Campus Mare Nostrum, University of Murcia, 30120 Murcia, Spain.ORCID 0000-0002-0773-4950
Instituto Murciano de Investigación Biosanitaria · ES

Funding

Fundación Séneca - Agencia de Ciencia y Tecnología de la Región de Murcia 21133/SF/19Fundación Séneca - Agencia de Ciencia y Tecnología de la Región de Murcia 21905/PI/22Ministerio de Ciencia e Innovación, Agencia Estatal de Investigación. PID2020-113557RB-I00Ministerio de Ciencia e Innovación, Agencia Estatal de Investigación. SAF2017-85679-R
6 · The paper itself

Abstract

Stress triggers relapses in cocaine use that engage the activity of memory-related nuclei, such as the basolateral amygdala (BLA) and dentate gyrus (DG). Preclinical research suggests that D3 receptor (D3R) antagonists may be a promising means to attenuate cocaine reward and relapse. As D3R regulates the activity of the Akt/mTOR and MEK/ERK

Indexed as

CocaineAnimalsConditioning, OperantCorticosteroneExtinction, PsychologicalMitogen-Activated Protein Kinase KinasesNitrilesProto-Oncogene Proteins c-aktReceptors, Dopamine D3RecurrenceStress, PhysiologicalStress, PsychologicalTetrahydroisoquinolinesCocaineCorticosteroneMitogen-Activated Protein Kinase KinasesNitrilesProto-Oncogene Proteins c-aktReceptors, Dopamine D3SB 277011Tetrahydroisoquinolinescocaine-induced conditioned place preferencedopaminergic receptorsdrug-seeking behaviorMEK1/2restrainttail pinch

Identifiers

PMID37446391
PMCPMC10342329
OpenAlexW4383818796

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.