Evidence map›Paper›PMID 37446306›Full record

ArticleInternational journal of molecular sciences2023

A C57BL/6J Fancg-KO Mouse Model Generated by CRISPR/Cas9 Partially Captures the Human Phenotype.

Ronak Shah, Paul C M van den Berk, Colin E J Pritchard, Ji-Ying Song, Maaike Kreft, Bas Pilzecker, Heinz Jacobs

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ronak ShahDepartment of Tumor Biology and Immunology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.
Paul C M van den BerkDepartment of Tumor Biology and Immunology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.
Colin E J PritchardMouse Clinic for Cancer and Aging Transgenic Facility, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.
Ji-Ying SongDepartment of Experimental Animal Pathology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.
Maaike KreftDepartment of Tumor Biology and Immunology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.
Bas PilzeckerDepartment of Tumor Biology and Immunology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.ORCID 0000-0002-3407-9197
Heinz JacobsDepartment of Tumor Biology and Immunology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.ORCID 0000-0001-6227-9850
The Netherlands Cancer Institute · NL

Funding

Dutch Cancer Society KWF NKI-2017- 10032 and KWF NKI-2017-10796 to Heinz Jacobs
6 · The paper itself

Abstract

Fanconi anemia (FA) develops due to a mutation in one of the FANC genes that are involved in the repair of interstrand crosslinks (ICLs). FANCG, a member of the FA core complex, is essential for ICL repair. Previous FANCG-deficient mouse models were generated with drug-based selection cassettes in mixed mice backgrounds, leading to a disparity in the interpretation of genotype-related phenotype. We created a

Indexed as

CisplatinFanconi AnemiaAnimalsCRISPR-Cas SystemsDNA-Binding ProteinsFanconi Anemia Complementation Group G ProteinFibroblastsHumansMiceMice, Inbred C57BLMitomycinPhenotypeCisplatinDNA-Binding ProteinsFancg protein, mouseFanconi Anemia Complementation Group G ProteinMitomycincisplatin (CsPt)CRISPR/Cas9DNA damage responseFANCGfanconi anemia (FA)genetically engineered mouse model (GEMM)hematopoiesisinterstrand crosslink (ICL)Mitomycin C (MMC)

Identifiers

PMID37446306
PMCPMC10342586
OpenAlexW4383368508

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.