Evidence map›Paper›PMID 37446292›Full record

ArticleInternational journal of molecular sciences2023

Triple-Isotope Tracing for Pathway Discernment of NMN-Induced NAD

Anthony A Sauve, Qinghui Wang, Ning Zhang, Seolhee Kang, Abigail Rathmann, Yue Yang

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06882096 (Tracing the Metabolic Flux of Orally Administered NAD+ Precursors in Healthy Young and Older Adults), which is not on this map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06882096 phase1recruitingnot on this mapstarted 2025, after this paper: background citation

Tracing the Metabolic Flux of Orally Administered NAD+ Precursors in Healthy Young and Older Adults

TypeinterventionalSponsorMetro International Biotech, LLCRan2025 to 2027Enrolled32ConditionsHealthy AdultsArmsNicotinamide Mononucleotide (NMN), Nicotinamide (NAM)
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. NADNature metabolism · 2025
    Review
  5. Article
  6. The role of NADnpj metabolic health and disease · 2025
    Review
  7. NRH, a potent NADMetabolism: clinical and experimental · 2025
    Article
  8. Review
  9. Review
  10. The role of nicotinamide adenine dinucleotide salvage enzymes in cardioprotection.Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery · 2024
    Review
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Anthony A SauveDepartment of Pharmacology, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA.
Qinghui WangDepartment of Pharmacology, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA.
Ning ZhangDepartment of Pharmacology, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA.ORCID 0000-0003-0909-6099
Seolhee KangDepartment of Pharmacology, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA.
Abigail RathmannDepartment of Pharmacology, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA.
Yue YangDepartment of Pharmacology, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA.ORCID 0000-0002-1481-8175
Cornell University · US

Funding

NAD Metabolism in Aging and Disease: Dysfunction and InterventionR01AG066192 · NIA · WEILL MEDICAL COLL OF CORNELL UNIV · PI YANG, YUE · 2020 to 2024
$1.7M
NIA NIH HHS 9R01AG066192-07NIA NIH HHS R01 AG066192
6 · The paper itself

Abstract

Numerous efforts in basic and clinical studies have explored the potential anti-aging and health-promoting effects of NAD

Indexed as

NADNicotinamide MononucleotideAgingAnimalsBiological TransportHumansMiceNADNicotinamide MononucleotideNAD+ metabolismnicotinamideNMNNRpharmacodynamics

Identifiers

PMID37446292
PMCPMC10342116
OpenAlexW4383347175

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.