ArticleInternational journal of molecular sciences2023
The Impact of Essential Trace Elements on Ovarian Response and Reproductive Outcomes following Single Euploid Embryo Transfer.
Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- The Impact of Minerals on Female Fertility: A Systematic Review.Nutrients · 2024Pooled it
- Cervicovaginal lavage fluid iron and manganese levels in women with and without vaginitis.BMC women's health · 2026Trial
- Association between heavy metals, essential trace elements in follicular fluid and diminished ovarian reserve: a hospital-based case-control study.Frontiers in endocrinology · 2026Article
- Associations of Essential and Non-Essential Trace Elements' Levels in the Blood, Serum, and Urine in Women with Premature Ovarian Insufficiency.Biological trace element research · 2025Article
- Using Life's Essential 8 and heavy metal exposure to determine infertility risk in American women: a machine learning prediction model based on the SHAP method.Frontiers in endocrinology · 2025Article
- Association between trace metal element concentrations in human blood plasma and early MAR embryological outcomes: a couple-based prospective cohort study.Human reproduction open · 2025Article
- Trace elements exposure affects the outcomes of in vitro fertilization embryo transfer, a cohort study in Northern China.Journal of assisted reproduction and genetics · 2024Article
- Associations between Non-Essential Trace Elements in Women's Biofluids and IVF Outcomes in Euploid Single-Embryo Transfer Cycles.Journal of xenobiotics · 2024Article
- Serum copper assessment in patients with polycystic ovary syndrome and tubal infertility: A retrospective 5-year study.Food science & nutrition · 2024Article
- Associations between follicular fluid trace elements and ovarian response during in vitro fertilization.Environmental research · 2024Article
- Article
- Review
- A Targeted Multi-Crystalline Manganese Oxide as a Tumor-Selective Nano-Sized MRI Contrast Agent for Early and Accurate Diagnosis of Tumors.International journal of nanomedicine · 2024Article
- EnhancingGynecology and minimally invasive therapyArticle
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Essential trace elements are required in extremely small amounts and obtained through diet. This research focuses on detecting major trace elements in different biofluids of sixty women undergoing ICSI with PGT-A and SET/FET at IVI-RMA, New Jersey, and assessing their impact on their IVF outcomes. Urine, plasma, and follicular fluid samples were collected on the vaginal oocyte retrieval day to measure the concentrations of eight essential trace elements (copper, zinc, molybdenum, lithium, selenium, manganese, chromium, and iron) using ICP-MS. After analysis, ovarian response and preimplantation outcomes had significant positive associations with both copper alone and the copper/zinc ratio in the follicular fluid and plasma, in addition to plasma manganese. Alternatively, elevated follicular fluid lithium concentrations were significantly associated with poor preimplantation outcomes while the urinary molybdenum concentration was significantly associated with a lower probability of implantation, clinical pregnancy, and live birth. Urinary lithium and chromium concentrations were significantly associated with a lower probability of achieving a live birth. Our results suggest that the essential trace elements present in follicular fluid, plasma, and urine of women are directly associated with their reproductive outcomes, with copper and manganese exerting positive effects and lithium and molybdenum exerting negative effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.