Evidence map›Paper›PMID 37446121›Full record

ArticleInternational journal of molecular sciences2023

Site-Specific RNA Editing of Stop Mutations in the CFTR mRNA of Human Bronchial Cultured Cells.

Roberta F Chiavetta, Simona Titoli, Viviana Barra, Patrizia Cancemi, Raffaella Melfi, Aldo Di Leonardo

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Targeting RNA adenosine editing and modification enzymes for RNA therapeutics.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Roberta F ChiavettaDepartment of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, 90128 Palermo, Italy.ORCID 0000-0002-5112-6549
Simona TitoliDepartment of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, 90128 Palermo, Italy.
Viviana BarraDepartment of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, 90128 Palermo, Italy.ORCID 0000-0002-7186-4485
Patrizia CancemiDepartment of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, 90128 Palermo, Italy.ORCID 0000-0002-3951-7213
Raffaella MelfiDepartment of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, 90128 Palermo, Italy.ORCID 0000-0003-4463-8156
Aldo Di LeonardoDepartment of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, 90128 Palermo, Italy.ORCID 0000-0003-4760-7179
University of Palermo · ITIstituto Zooprofilattico Sperimentale Della Sicilia · IT

Funding

Fondazione Ricerca Fibrosi Cistica FFC#5 2021
6 · The paper itself

Abstract

It is reported that about 10% of cystic fibrosis (CF) patients worldwide have nonsense (stop) mutations in the CFTR gene, which cause the premature termination of CFTR protein synthesis, leading to a truncated and non-functional protein. To address this issue, we investigated the possibility of rescuing the

Indexed as

Cystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorCell LineCodon, TerminatorHumansMutationRNA EditingRNA, MessengerCFTR protein, humanCodon, TerminatorCystic Fibrosis Transmembrane Conductance RegulatorRNA, MessengerCRISPR/dCas13cystic fibrosismxABEpremature termination codons (PTCs)REPAIRv2RNA editing

Identifiers

PMID37446121
PMCPMC10342162
OpenAlexW4382653109

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.