Evidence map›Paper›PMID 37446093›Full record

ArticleInternational journal of molecular sciences2023

Motifs in Natural Products as Useful Scaffolds to Obtain Novel Benzo[

Analia Young Hwa Cho, Hery Chung, Javier Romero-Parra, Poulami Kumar, Marco Allarà, Alessia Ligresti, Carlos Gallardo-Garrido, Hernán Pessoa-Mahana, Mario Faúndez, Carlos David Pessoa-Mahana

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Synthesis of Novel Chloro-Benzo [Pharmaceuticals (Basel, Switzerland) · 2025
    Article
  3. Benzo[International journal of molecular sciences · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Analia Young Hwa ChoPharmacy Department, Faculty of Chemistry, Pontificia Universidad Católica de Chile, Vicuña Mackenna 4860, Santiago 7820436, Chile.
Hery ChungPharmacy Department, Faculty of Chemistry, Pontificia Universidad Católica de Chile, Vicuña Mackenna 4860, Santiago 7820436, Chile.
Javier Romero-ParraOrganic Chemistry and Physical Chemistry Department, Faculty of Chemical and Pharmaceutical Sciences, Universidad de Chile, Olivos 1007, Santiago 7820436, Chile.
Poulami KumarNational Research Council of Italy, Institute of Biomolecular Chemistry, 80078 Pozzuoli, Italy.ORCID 0000-0001-7138-218X
Marco AllaràNational Research Council of Italy, Institute of Biomolecular Chemistry, 80078 Pozzuoli, Italy.
Alessia LigrestiNational Research Council of Italy, Institute of Biomolecular Chemistry, 80078 Pozzuoli, Italy.ORCID 0000-0003-1787-3900
Carlos Gallardo-GarridoPharmacy Department, Faculty of Chemistry, Pontificia Universidad Católica de Chile, Vicuña Mackenna 4860, Santiago 7820436, Chile.ORCID 0000-0002-7837-6003
Hernán Pessoa-MahanaOrganic Chemistry and Physical Chemistry Department, Faculty of Chemical and Pharmaceutical Sciences, Universidad de Chile, Olivos 1007, Santiago 7820436, Chile.
Mario FaúndezPharmacy Department, Faculty of Chemistry, Pontificia Universidad Católica de Chile, Vicuña Mackenna 4860, Santiago 7820436, Chile.
Carlos David Pessoa-MahanaPharmacy Department, Faculty of Chemistry, Pontificia Universidad Católica de Chile, Vicuña Mackenna 4860, Santiago 7820436, Chile.
Pontificia Universidad Católica de Chile · CLNational Research Council · ITUniversity of Chile · CL

Funding

Agencia Nacional de Investigación y Desarrollo 11190145Agencia Nacional de Investigación y Desarrollo 1150121
6 · The paper itself

Abstract

The endocannabinoid system (ECS) constitutes a broad-spectrum modulator of homeostasis in mammals, providing therapeutic opportunities for several pathologies. Its two main receptors, cannabinoid type 1 (CB1) and type 2 (CB2) receptors, mediate anti-inflammatory responses; however, their differing patterns of expression make the development of CB2-selective ligands therapeutically more attractive. The benzo[

Indexed as

Biological ProductsCannabinoidsAnimalsCannabinoid Receptor AgonistsImidazolesMammalsReceptor, Cannabinoid, CB1Receptor, Cannabinoid, CB2Structure-Activity RelationshipBiological ProductsCannabinoid Receptor AgonistsCannabinoidsimidazoleImidazolesReceptor, Cannabinoid, CB1Receptor, Cannabinoid, CB2benzimidazolescannabinoid receptorCB2 agonistsnatural productssynthesis

Identifiers

PMID37446093
PMCPMC10341893
OpenAlexW4382752906

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.